Three-dimensional thermophotonic super-resolution imaging with biomedical and NDI applications by spatiotemporal diffusion-reversal methods
Andreas Mandelis, Center for Advanced Diffusion-Wave and Photoacoustic Technologies and Institute for Advanced Non-Destructive and Non-Invasive Diagnostic Technologies, Univ. of Toronto (Canada)
The combination of spatial second derivative forming, spatial gradient adaptive filtering, experimental photothermal point spread function (PPSF) construction, and Richardson-Lucy deconvolution allowed for the achievement of spatial super-resolution in thermophotonic imaging. This is a breakthrough since traditional limitations, which are caused by lateral and axial heat diffusion, were overcome. With enhanced truncation-correlation photothermal coherence tomography (eTC-PCT), it was possible to restore blurred infrared thermophotonic images to their pre-diffusion optical resolution state. This modality was tested in various biological applications and proved to be capable of imaging fine axial cracks in human teeth, well-patterned anatomical subsurface structures of the mouse brain, and neovascularization in a mouse thigh due to the rapid proliferation of cancer cells. The modality was found to be immune to optical scattering and could reveal the true spatial extent of biological features at subsurface depths that conventional thermal imaging cannot reach due to limitations imposed by the physics of spreading diffusion. In a recent non-destructive imaging application the super-resolution method produced non-destructive 3D images of metal cracks in manufacturing components.
Andreas Mandelis is a Full Professor of Mechanical & Industrial Engineering; Electrical & Computer Engineering; and the Institute of Biomaterials & Biomedical Engineering, University of Toronto. Dr. Mandelis’ fundamental research interests are focused on studies of physical processes in condensed and biological matter as they impact instrumentation science and signal generation. Examples are thermophysics, non-radiative and radiative physics of electronic, optical and biomedical materials, photoacoustic, photothermal and diffusion-wave phenomena in manufactured, electronic, biological and photonic media. Professor Mandelis is the Canada Research Chair (Tier 1) in Diffusion-Wave Sciences and Technologies and a Fellow in the Academy of Sciences of The Royal Society of Canada. He has been selected for the Alexander von Humboldt Professor Award twice (in 2003 and 2012). He is the 2007 (inaugural) recipient of the Ontario Premier’s Discovery Award in Science and Engineering. He received the ASME 2009 Yeram Touloukian Award (and Medal) in Thermophysics, the Senior Prize of the International Photoacoustic and Photothermal Association, and the Canadian Association of Physicists (CAP) Medal for Outstanding Achievement in Industrial and Applied Physics. In 2010 he was awarded a Killam Research Fellowship from the Canada Council for the Arts. He is the recipient of the American Physical Society’s (APS) 2012 Joseph F. Keithley Award for Advances in Measurement Science and of the CAP-INO Medal for Outstanding Achievement in Applied Photonics. In 2013 he was selected as one of 10 recipients of the 2013 University of Toronto Inventors of the Year Award. He is a Fellow of the Canadian Academy of Engineering, the APS, the SPIE, the AAAS and the ASME.
This keynote is part of the Thermosense: Thermal Infrared Applications conference.
Event Details
FORMAT: Presentation followed by audience Q&A.MENU: Coffee, decaf, and tea will be available in the exhibition area.
SETUP: Classroom and theater style seating. .