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Herbert Schneckenburger

 Prof. Dr. Herbert Schneckenburger

Professor of Optics and Biophotonics
Aalen University
Institute of Applied Research

Aalen  73430

E-mail: Herbert.Schneckenburger@hs-aalen.de

Area of Expertise

Optical microscopy (fluorescence, scattering, confocal, light sheet, TIR, structured illumination, laser micro-manipulation), biomedical spectroscopy (spectral imaging, FLIM, FRET)


Herbert Schneckenburger is a professor of Optics and Biophotonics at Aalen University and a private lecturer of the Medical Faculty of the University of Ulm. He received his PhD in Physics from the University of Stuttgart in 1979 and his habilitation in Biomedical Technology from the University of Ulm in 1992. His research is focused on various fields of biomedical optics including optical 3D microscopy and time-resolved laser spectroscopy. In the period of 1979-2017 Prof. Schneckenburger published more than 260 scientific articles, received 6 patents and managed and performed 34 projects with third-party funding. He is continuously active as an international expert in his field.

Lecture Title(s)

3D Live Cell Microscopy

3D microscopy of living cells, tissue samples and small organisms is reported. In particular, the lecture shows how information from various focal planes of a microscope can be obtained and combined in a 3D image. Relevant techniques include Confocal Laser Scanning Microscopy (CLSM), Structured Illumination Microscopy (SIM) and Light Sheet based Fluorescence Microscopy (LSFM). While LSFM permits the lowest light exposure and allows cells to remain viable even over prolonged measuring procedures, SIM permits the highest resolution and - in combination with axial tomography - represents an important step towards super-resolution microscopy. Finally, it will be demonstrated how fluorescence measurements can support laser micromanipulation and laser tweezer experiments.

Biomedical spectroscopy

Laser-assisted methods of microspectral analysis and spectral imaging as well as of fluorescence lifetime imaging (FLIM) and Förster Resonance Energy Transfer (FRET) are reported. In particular, fluorescence spectra and lifetimes of a molecule will be introduced as very sensitive parameters to probe conformations and interactions of a molecule with its micro-environment. Applications are focused on the detection of diseases (e.g. cancer, Alzheimer's disease), drug response or initiation of apoptosis.

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