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Proceedings Paper

Functional imaging of tumor vascular network in small animal models
Author(s): Vyacheslav Kalchenko; Noa Madar-Balakirski; Yuri Kuznetsov; Igor Meglinski; Alon Harmelin
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Paper Abstract

In current report we present synchronized in vivo imaging of tumor vascular network and tumor microenvironment obtained by combined use of Dynamic Light Scattering Imaging, Spectrally Enhanced Microscopy, and Fluorescence Intravital Microscopy. Dynamic Light Scattering Imaging is used for functional imaging of the vascular network and blood microcirculation. Spectrally Enhanced Microscopy provides information regarding blood vessel topography. Fluorescence Intravital Microscopy is used for imaging of tumor microvasculature and tumor microenvironment. These well known modalities have been comprehensively validated in the past and are widely used in various bio-medical applications. As shown here, their combined application has great potential for studies of vascular biology. This multi-modal non-invasive diagnostic technique expands our current capacity to investigate blood microcirculation and tumor angiogenesis in vivo, thereby contributing to the development of cancer research and treatment.

Paper Details

Date Published: 9 June 2011
PDF: 4 pages
Proc. SPIE 8090, Novel Biophotonic Techniques and Applications, 809007 (9 June 2011); doi: 10.1117/12.890746
Show Author Affiliations
Vyacheslav Kalchenko, Weizmann Institute of Science (Israel)
Noa Madar-Balakirski, Weizmann Institute of Science (Israel)
Yuri Kuznetsov, Weizmann Institute of Science (Israel)
Igor Meglinski, Univ. of Otago (New Zealand)
Alon Harmelin, Weizmann Institute of Science (Israel)

Published in SPIE Proceedings Vol. 8090:
Novel Biophotonic Techniques and Applications
Henricus J. C. M. Sterenborg; I. Alex Vitkin, Editor(s)

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