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Proceedings Paper

In vivo optical detection of brain tumor and tumor margin: a combined autofluorescence and diffuse reflectance spectroscopic study
Author(s): Shovan K. Majumder; Steven Gebhart; Reid Thompson M.D.; Kyle D. Weaver M.D.; Mahlon D. Johnson; Wei-Chiang Lin; Anita Mahadevan-Jansen
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Paper Abstract

Recently, optical spectroscopy has shown considerable promise to be used as a potential clinical tool for human brain tumor detection and therapeutic guidance. Our group showed for the first time the possibility of using combined autofluorescence and diffuse reflectance spectroscopy and established its applicability for human brain tumor demarcation in previous in vitro and in vivo studies. We report in this paper the results of a clinical study designed to further evaluate the efficacy of the approach for demarcation of brain tumors and tumor margins from normal brain tissues in intra-operative clinical setting. Using a portable system, optical spectra were collected from the brain of 110 patients undergoing craniotomy at the Vanderbilt University Medical Center. Spectral measurements were taken from multiple sites of tumor core, tumor margin and normal areas of brain tissues and the resulting spectra were correlated with the corresponding histopathologic diagnosis. Using histology as the gold standard, a probabilistic multi-class diagnostic algorithm was developed to simultaneously distinguish tumor core and tumor margin from normal brain tissue sites using independent training and validation sets of data. An unbiased estimate of the accuracy of the model indicates that combined autofluorescence and diffuse reflectance spectroscopy was able to distinguish tumor core and tumor margin from normal brain tissues with an average predictive accuracy of ~88%.

Paper Details

Date Published: 7 February 2007
PDF: 10 pages
Proc. SPIE 6430, Advanced Biomedical and Clinical Diagnostic Systems V, 64300F (7 February 2007); doi: 10.1117/12.724875
Show Author Affiliations
Shovan K. Majumder, Vanderbilt Univ. (United States)
Steven Gebhart, Vanderbilt Univ. (United States)
Reid Thompson M.D., Vanderbilt Univ. (United States)
Kyle D. Weaver M.D., Vanderbilt Univ. (United States)
Mahlon D. Johnson, Univ. of Rochester Medical Ctr. (United States)
Wei-Chiang Lin, Florida International Univ. (United States)
Anita Mahadevan-Jansen, Vanderbilt Univ. (United States)

Published in SPIE Proceedings Vol. 6430:
Advanced Biomedical and Clinical Diagnostic Systems V
Ramesh Raghavachari; Tuan Vo-Dinh; Warren S. Grundfest M.D.; David A. Benaron M.D.; Gerald E. Cohn, Editor(s)

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