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Proceedings Paper

Vascular-targeted photodynamic of prostate cancer phase with Tookad for recurrent prostate cancer following radiation therapy: initial clinical studies
Author(s): Robert A. Weersink; Brian C. Wilson; Arjen Bogaards; Mark R. Gertner; Sean R. H. Davidson; Masoom A. Haider; Mostafa Elhilali M.D.; John Trachtenberg M.D.
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Paper Abstract

We report on the first clinical application of vascular-targeted photodynamic therapy using a bacteriopheophorbide derivative, Tookad, in patients with localized prostate cancer following external beam radiation therapy. Patients received either escalating intravenous drug doses at a fixed light dose or escalated light doses at the highest photosensitizer dose. Two cylindrically diffusing fibers were placed transperineally in the prostate, along with light monitoring fibers in the prostate, urethra and rectum. Treatment response was assessed with 7-day gadolinium-enhanced T1-weighted MRI and 6-month biopsy. Lesion formation was strongly drug and light dose-dependent, with an apparent threshold response. Early biochemical and MRI responses support the clinical potential of TOOKAD-PDT to treat locally-recurrent prostate cancer.

Paper Details

Date Published: 23 March 2007
PDF: 10 pages
Proc. SPIE 6424, Photonic Therapeutics and Diagnostics III, 64241E (23 March 2007); doi: 10.1117/12.704398
Show Author Affiliations
Robert A. Weersink, Ontario Cancer Institute/Univ. of Toronto (Canada)
Brian C. Wilson, Ontario Cancer Institute/Univ. of Toronto (Canada)
Arjen Bogaards, Ontario Cancer Institute/Univ. of Toronto (Canada)
Mark R. Gertner, Ontario Cancer Institute/Univ. of Toronto (Canada)
Sean R. H. Davidson, Ontario Cancer Institute/Univ. of Toronto (Canada)
Masoom A. Haider, Ontario Cancer Institute/Univ. of Toronto (Canada)
Mostafa Elhilali M.D., McGill Univ. (Canada)
John Trachtenberg M.D., Princess Margaret Hospital/Univ. Health Network/Univ. of Toronto (Canada)

Published in SPIE Proceedings Vol. 6424:
Photonic Therapeutics and Diagnostics III
Henry Hirschberg M.D.; Brian Jet-Fei Wong M.D.; Reza S. Malek M.D.; Kenton W. Gregory M.D.; Nikiforos Kollias M.D.; Bernard Choi; Steen J. Madsen; Guillermo J. Tearney M.D.; Justus F. R. Ilgner M.D.; Haishan Zeng, Editor(s)

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