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Proceedings Paper

Clinical data analysis for the combined optical and tomosynthesis breast imaging
Author(s): Qianqian Fang; Juliette Selb; Stefan A. Carp; Greg Boverman; Daniel B. Kopans; Richard H. Moore; David A. Boas
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Paper Abstract

Combining 2D X-ray mammography or 3D tomosynthesis with diffuse optical tomography for breast imaging is advantageous in facilitating clinical diagnosis by fusing the structural X-ray images with functional optical images. In this study, we imaged 65 patients with a combined tomosynthesis/diffuse optical breast imaging system developed at Massachusetts General Hospital. The bulk optical properties and patient demographics were summarized in this paper. The averaged total-hemoglobin for 60 healthy breasts is 21 &mgr;M which is comparable with literature values given the applied mammographic compression in our experiments. The averaged oxygen saturation is 76%. The comparison of contra-lateral breast measurements also demonstrated correlations in total hemoglobin and oxygen saturation. Image reconstructions of the healthy breasts with moderate-sized fibroglandular regions correctly recovered the chest-wall muscle, fibro-glandular tissue as well as the surrounding fatty tissue. For dense breasts, the contrast between the chest-wall and the fibro-glandular region is small and the most pronounced feature of the image is a low-absorption region in the center of the breast. We hypothesized that this is caused by pressure induced blood-redistribution. Supportive evidence for this hypothesis had been shown with mechanical simulations of breast compression.

Paper Details

Date Published: 20 February 2007
PDF: 9 pages
Proc. SPIE 6431, Multimodal Biomedical Imaging II, 64310H (20 February 2007); doi: 10.1117/12.701623
Show Author Affiliations
Qianqian Fang, Massachusetts General Hospital (United States)
Juliette Selb, Massachusetts General Hospital (United States)
Stefan A. Carp, Massachusetts General Hospital (United States)
Greg Boverman, Northeastern Univ. (United States)
Daniel B. Kopans, Massachusetts General Hospital (United States)
Richard H. Moore, Massachusetts General Hospital (United States)
David A. Boas, Massachusetts General Hospital (United States)

Published in SPIE Proceedings Vol. 6431:
Multimodal Biomedical Imaging II
Fred S. Azar, Editor(s)

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