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Proceedings Paper

Novel optical spectroscopy system for breast cancer diagnostics
Author(s): Natalia Shakhova; Ilya Turchin; Vladislav Kamensky; Ekaterina Sergeeva; German Golubyatnikov; Luiz Da Silva; Usha Kasthuri; Irina Pavlycheva; Svetlana Smetanina; Anna Artifeksova; Sergey Belkov; Gennady Kochemasov
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Paper Abstract

We report on development of minimally invasive system for immediate diagnostics of breast cancer and on the results of its pilot clinical testing. The system designed by BioTelligent Inc is based on analysis of optical diffusion spectra (ODS) measured by a probe inserted into breast tissue during standard punch biopsy. Analysis of scattered spectra aimed to distinction of benign tumors from malignant ones is done by original procedure of data processing. Clinical testing of the created diagnostic system has been performed by classification of spectra collected from 146 patients with previously detected mammary neoplasms. The data of ODS study in each patient have been compared to the results of histology. The proposed technique has to date demonstrated sensitivity of 96%, specificity of 80% and diagnostic accuracy of 88%. These values are expected to improve as the data sets continue to grow and more sophisticated data processing is employed.

Paper Details

Date Published: 13 February 2007
PDF: 7 pages
Proc. SPIE 6430, Advanced Biomedical and Clinical Diagnostic Systems V, 64300N (13 February 2007); doi: 10.1117/12.700656
Show Author Affiliations
Natalia Shakhova, Institute of Applied Physics (Russia)
Ilya Turchin, Institute of Applied Physics (Russia)
Vladislav Kamensky, Institute of Applied Physics (Russia)
Ekaterina Sergeeva, Institute of Applied Physics (Russia)
German Golubyatnikov, Institute of Applied Physics (Russia)
Luiz Da Silva, BioTelligent (United States)
Usha Kasthuri, BioTelligent (United States)
Irina Pavlycheva, Nizhny Novgorod State Medical Academy (Russia)
Svetlana Smetanina, Nizhny Novgorod State Medical Academy (Russia)
Anna Artifeksova, Nizhny Novgorod State Medical Academy (Russia)
Sergey Belkov, BIOFIL Ltd. (Russia)
Gennady Kochemasov, BIOFIL Ltd. (Russia)

Published in SPIE Proceedings Vol. 6430:
Advanced Biomedical and Clinical Diagnostic Systems V
Ramesh Raghavachari; Tuan Vo-Dinh; Warren S. Grundfest M.D.; David A. Benaron M.D.; Gerald E. Cohn, Editor(s)

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