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Proceedings Paper

Retinal multimodal imaging for identification of novel biomarkers for early detection of Alzheimer's disease (Conference Presentation)
Author(s): Ygal Rotenstreich; Inbal Sharvit-Ginon; Michal Schnaider Beeri; Ramit Ravona-Springer ; Ido Fabian ; Ofira Zloto; Aron Weller; Ifat Sher

Paper Abstract

Purpose: To identify early retinal biomarkers for Alzheimer disease (AD) using multimodal imaging. Methods: Infra-red (IR) and multicolor fundus imaging and spectral domain optic coherence tomography (SD-OCT) were performed in 108 offspring of AD patients (FH+) and 44 age-matched controls (FH-). All subjects were tested for cognitive function by executive function and episodic memory tests. MRI brain imaging was performed on a 3T MRI. Results: In FH+ subjects, lower performance in memory was associated with thicker peri-papillary temporal-superior RNFL (r=-0.220; p=.016). In FH- subjects, the correlation was in the opposite direction (r=0.335; p=.013). In FH+, left Hippocampal volume was associated with larger total macular thickness (r=0.212; p=.028), as well as thicker macular RNFL (r=0.216; p=.025), macular GCL (r=0.221; p=.022), and macular IPL (r=0.285, p=.003). Similar results were found in the right eye. Conclusions: The thickness of inner retinal layers and peripapillary RNFL are associated with cognitive functioning and hippocampal volume in asymptomatic subjects at high risk for AD and may present novel biomarkers for very early detection of AD.

Paper Details

Date Published: 13 March 2019
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Proc. SPIE 10858, Ophthalmic Technologies XXIX, 1085818 (13 March 2019); doi: 10.1117/12.2509262
Show Author Affiliations
Ygal Rotenstreich, The Chaim Sheba Medical Ctr., Tel Hashomer (Israel)
Inbal Sharvit-Ginon, The Chaim Sheba Medical Ctr., Tel Hashomer (Israel)
Bar-Ilan Univ. (Israel)
Michal Schnaider Beeri, The Chaim Sheba Medical Ctr., Tel Hashomer (Israel)
Icahn School of Medicine at Mount Sinai (United States)
Ramit Ravona-Springer , The Chaim Sheba Medical Ctr., Tel Hashomer (Israel)
Tel Aviv Univ. (Israel)
Ido Fabian , The Chaim Sheba Medical Ctr., Tel Hashomer (Israel)
Ofira Zloto, The Chaim Sheba Medical Ctr. Tel Hashomer (Israel)
Aron Weller, Bar-Ilan Univ. (Israel)
Ifat Sher, The Chaim Sheba Medical Ctr., Tel Hashomer (Israel)


Published in SPIE Proceedings Vol. 10858:
Ophthalmic Technologies XXIX
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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