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Proceedings Paper

Hyperspectral imaging for intraoperative diagnosis of colon cancer metastasis in a liver
Author(s): Ivica Kopriva; Gorana Aralica M.D.; Marijana Popović Hadžija M.D.; Mirko Hadžija M.D.; Laura-Isabelle Dion-Bertrand; Xinjian Chen
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Paper Abstract

Hyperspectral imaging (HSI) is being shown as an emerging modality with a great potential in disease diagnosis and surgical cancer resection. Herein, we evaluate feasibility of the HSI to discriminate and diagnose colon cancer metastasis in a liver from five hematoxylin and eosin stained histopathological specimens. They were collected from the same patient during intraoperative frozen section analysis. Cancer and non-cancer spectra along with corresponding spatial maps were estimated from hyperspectral images by means of spectral unmixing. It was found that maximal angle between cancer spectra is 1.02 degrees less than minimal angle between cancer vs. non-cancer spectra. Thus, spectrum angle mapper was used for pixel-based diagnosis of cancer yielding sensitivity between 81.23% and 97.12%, specificity between 85.85% and 97.3%, and accuracy between 86.85% and 96.92%.

Paper Details

Date Published: 18 March 2019
PDF: 11 pages
Proc. SPIE 10956, Medical Imaging 2019: Digital Pathology, 109560S (18 March 2019); doi: 10.1117/12.2503907
Show Author Affiliations
Ivica Kopriva, Ruder Boškovic Institute (Croatia)
Gorana Aralica M.D., Clinical Hospital Dubrava (Croatia)
School of Medicine, Univ. of Zagreb (Croatia)
Marijana Popović Hadžija M.D., Ruder Boškovic Institute (Croatia)
Mirko Hadžija M.D., Ruder Boškovic Institute (Croatia)
Laura-Isabelle Dion-Bertrand, Photon etc. (Canada)
Xinjian Chen, Soochow Univ. (China)

Published in SPIE Proceedings Vol. 10956:
Medical Imaging 2019: Digital Pathology
John E. Tomaszewski; Aaron D. Ward, Editor(s)

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