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Proceedings Paper

Prognosis classification in glioblastoma multiforme using multimodal MRI derived heterogeneity textural features: impact of pre-processing choices
Author(s): Taman Upadhaya; Yannick Morvan; Eric Stindel; Pierre-Jean Le Reste; Mathieu Hatt
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Paper Abstract

Heterogeneity image-derived features of Glioblastoma multiforme (GBM) tumors from multimodal MRI sequences may provide higher prognostic value than standard parameters used in routine clinical practice. We previously developed a framework for automatic extraction and combination of image-derived features (also called “Radiomics”) through support vector machines (SVM) for predictive model building. The results we obtained in a cohort of 40 GBM suggested these features could be used to identify patients with poorer outcome. However, extraction of these features is a delicate multi-step process and their values may therefore depend on the pre-processing of images. The original developed workflow included skull removal, bias homogeneity correction, and multimodal tumor segmentation, followed by textural features computation, and lastly ranking, selection and combination through a SVM-based classifier. The goal of the present work was to specifically investigate the potential benefit and respective impact of the addition of several MRI pre-processing steps (spatial resampling for isotropic voxels, intensities quantization and normalization) before textural features computation, on the resulting accuracy of the classifier. Eighteen patients datasets were also added for the present work (58 patients in total). A classification accuracy of 83% (sensitivity 79%, specificity 85%) was obtained using the original framework. The addition of the new pre-processing steps increased it to 93% (sensitivity 93%, specificity 93%) in identifying patients with poorer survival (below the median of 12 months). Among the three considered pre-processing steps, spatial resampling was found to have the most important impact. This shows the crucial importance of investigating appropriate image pre-processing steps to be used for methodologies based on textural features extraction in medical imaging.

Paper Details

Date Published: 24 March 2016
PDF: 8 pages
Proc. SPIE 9785, Medical Imaging 2016: Computer-Aided Diagnosis, 97850W (24 March 2016); doi: 10.1117/12.2217151
Show Author Affiliations
Taman Upadhaya, b<>com Institute of Research and Technologies (France)
Univ. of Western Brittany (France)
Yannick Morvan, b<>com Institute of Research and Technologies (France)
Eric Stindel, LaTIM (France)
Univ. of Western Brittany (France)
Pierre-Jean Le Reste, Univ. Hospital Pontchaillou (France)
Mathieu Hatt, LaTIM (France)

Published in SPIE Proceedings Vol. 9785:
Medical Imaging 2016: Computer-Aided Diagnosis
Georgia D. Tourassi; Samuel G. Armato III, Editor(s)

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