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Proceedings Paper

Diagnostic accuracy of integrated intravascular ultrasound and optical coherence tomography (IVUS-OCT) system for coronary plaque characterization
Author(s): Jiawen Li; Teng Ma; Dilbahar Mohar; Adrian Correa; Hataka Minami; Joseph Jing; Qifa Zhou; Pranav M. Patel; Zhongping Chen
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Paper Abstract

Intravascular ultrasound (IVUS) imaging and optical coherence tomography (OCT), two commonly used intracoronary imaging modalities, play important roles in plaque evaluation. The combined use of IVUS (to visualize the entire plaque volume) and OCT (to quantify the thickness of the plaque cap, if any) is hypothesized to increase plaque diagnostic accuracy. Our group has developed a fully-integrated dual-modality IVUS-OCT imaging system and 3.6F catheter for simultaneous IVUS-OCT imaging with a high resolution and deep penetration depth. However, the diagnostic accuracy of an integrated IVUS-OCT system has not been investigated. In this study, we imaged 175 coronary artery sites (241 regions of interest) from 20 cadavers using our previous reported integrated IVUS-OCT system. IVUS-OCT images were read by two skilled interventional cardiologists. Each region of interest was classified as either calcification, lipid pool or fibrosis. Comparing the diagnosis by cardiologists using IVUSOCT images with the diagnosis by the pathologist, we calculated the sensitivity and specificity for characterization of calcification, lipid pool or fibrosis with this integrated system. In vitro imaging of cadaver coronary specimens demonstrated the complementary nature of these two modalities for plaques classification. A higher accuracy was shown than using a single modality alone.

Paper Details

Date Published: 4 March 2014
PDF: 6 pages
Proc. SPIE 8926, Photonic Therapeutics and Diagnostics X, 892635 (4 March 2014); doi: 10.1117/12.2037886
Show Author Affiliations
Jiawen Li, Beckman Laser Institute (United States)
Univ. of California, Irvine (United States)
Teng Ma, Univ. of Southern California, Los Angeles (United States)
Dilbahar Mohar, Beckman Laser Institute (United States)
Adrian Correa, Univ. of Southern California, Los Angeles (United States)
Hataka Minami, Beckman Laser Institute (United States)
Joseph Jing, Beckman Laser Institute (United States)
Univ. of California, Irvine (United States)
Qifa Zhou, Univ. of Southern California, Los Angeles (United States)
Pranav M. Patel, Univ. of California, Irvine (United States)
Zhongping Chen, Beckman Laser Institute (United States)
Univ. of California, Irvine (United States)

Published in SPIE Proceedings Vol. 8926:
Photonic Therapeutics and Diagnostics X
Bernard Choi; Hyun Wook Kang; Brian J. F. Wong M.D.; Guillermo J. Tearney M.D.; Andreas Mandelis; Nikiforos Kollias; Kenton W. Gregory M.D.; Justus F. Ilgner M.D.; Haishan Zeng; Laura Marcu, Editor(s)

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