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Proceedings Paper

Determination of tissue optical properties in PDT treated head and neck patients
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Paper Abstract

Determination of optical properties (absorption (μa) and scattering (μs’) coefficients) in human tissue is important when it comes to accurate calculation of fluence rate in and around tissue area. ALA application to the tissue induces production of protoporphyrin IX when activated by red light. Changes in the tissue optical properties can send information such as treatment outcome and tissue drug concentration. Patients in this study were treated with PDT for head and neck mucosal dysplasia. They were enrolled in a phase I study of escalating light doses and oral ALA with 60mg/kg. Red light at 630nm was administered to the tumor from a laser. The light dose was escalated from 50-200J/cm2 with a measured fluence rate at tissue surface of 100mW/cm2. We developed a light detection device for the purpose of determining optical properties in vivo using the semi-infinite method. The light detection device consists of two parallel, placed 5mm apart. In one of the catheters a 2 mm long linear diffusing light source is placed while in the second catheter, a calibrated isotropic detector is placed. The detector is scanned along the length of the light source containing catheter. Scans are done with the device placed on the treatment area (tumor) and on the normal tissue. Optical properties were measured in-vivo before and after PDT delivery for both normal tissue and tumor.

Paper Details

Date Published: 28 March 2014
PDF: 9 pages
Proc. SPIE 8926, Photonic Therapeutics and Diagnostics X, 89262C (28 March 2014); doi: 10.1117/12.2037831
Show Author Affiliations
Andreea Dimofte, The Univ. of Pennsylvania Health System (United States)
Jarod C. Finlay, The Univ. of Pennsylvania Health System (United States)
Anna V. Sharikova, The Univ. of Pennsylvania Health System (United States)
Keith A. Cengel, Univ. of Pennsylvania School of Medicine (United States)
Peter Ahn, The Univ. of Pennsylvania Health System (United States)
Theresa M. Busch, The Univ. of Pennsylvania Health System (United States)
Timothy C. Zhu, The Univ. of Pennsylvania Health System (United States)

Published in SPIE Proceedings Vol. 8926:
Photonic Therapeutics and Diagnostics X
Bernard Choi; Hyun Wook Kang; Brian J. F. Wong M.D.; Guillermo J. Tearney M.D.; Andreas Mandelis; Nikiforos Kollias; Kenton W. Gregory M.D.; Justus F. Ilgner M.D.; Haishan Zeng; Laura Marcu, Editor(s)

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