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Proceedings Paper

Electrophysiological and histological effects on canine right atrium by photosensitization reaction under catheterization in vivo
Author(s): M. Takahashi; E. Ogawa; S. Motohashi; T. Nakamura; H. Kawakami; N. Machida; A. Ito; T. Kimura; S. Takatsuki; K. Fukumoto; S. Miyoshi; K. Fukuda; T. Arai
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Paper Abstract

We investigated electrophysiological and histological effect on canine anatomical isthmus in right atrium by photosensitization reaction (PR) of talaporfin sodium operated via a manipulative 7 Fr. laser catheter to establish a nonthermal tachyarrhythmia treatment. We continuously administrated talaporfin sodium via a left femoral vein to maintain photosensitizer concentration of 25-35 μg/ml in blood plasma, which is within the range of clinical use in human. Fifteen-minute after kickoff of the photosensitizer administration, a 663 nm laser was irradiated via the laser catheter for 30 s/point with irradiance of 10 W/cm2. After 17 times irradiations, a 23 ms delay of the electrical signal propagation along tricuspid annulus was observed. This result might demonstrate the acute electrical conduction delay induced by PR. The canine heart was extracted 10 days after PR and Azan staining specimen was histologically evaluated to investigate the myocardial damage by PR. The transmural fibrosis in anatomical isthmus was found. We demonstrated the PR-induced electrical conduction delay in acute phase in vivo using continuous photosensitizer dosed canine model, which maintain the clinical photosensitizer concentrat

Paper Details

Date Published: 8 March 2013
PDF: 6 pages
Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 85654A (8 March 2013); doi: 10.1117/12.2000619
Show Author Affiliations
M. Takahashi, Keio Univ. (Japan)
E. Ogawa, Keio Univ. (Japan)
S. Motohashi, Keio Univ. (Japan)
T. Nakamura, Keio Univ. (Japan)
H. Kawakami, Keio Univ. (Japan)
N. Machida, Keio Univ. (Japan)
A. Ito, Keio Univ. (Japan)
T. Kimura, Keio Univ. School of Medicine (Japan)
S. Takatsuki, Keio Univ. School of Medicine (Japan)
K. Fukumoto, Keio Univ. School of Medicine (Japan)
S. Miyoshi, Keio Univ. School of Medicine (Japan)
K. Fukuda, Keio Univ. School of Medicine (Japan)
T. Arai, Keio Univ. (Japan)


Published in SPIE Proceedings Vol. 8565:
Photonic Therapeutics and Diagnostics IX
Andreas Mandelis; Brian Jet-Fei Wong; Anita Mahadevan-Jansen; Henry Hirschberg M.D.; Hyun Wook Kang; Nikiforos Kollias; Melissa J. Suter; Kenton W. Gregory M.D.; Guillermo J. Tearney M.D.; Stephen Lam; Bernard Choi; Steen J. Madsen; Bodo E. Knudsen M.D.; E. Duco Jansen; Justus F. Ilgner M.D.; Haishan Zeng; Matthew Brenner; Laura Marcu, Editor(s)

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