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Conference 13006 > Paper 13006-36
Paper 13006-36

Towards cutaneous blood flow velocity estimation using VISTA processing on a 1.6 MHz FDML OCT system

10 April 2024 • 09:40 - 10:00 CEST | Etoile B, Niveau/Level 1

Abstract

Atopic dermatitis (AD) often induces vasodilation, potentially impacting the velocity of blood flow within capillaries and vessels. To quantify the velocity change, we have developed and tested a 1.67 MHz 1310 nm Fourier-domain mode-locked (FDML) OCT system for measuring the decorrelation coefficient in blood vessels. This system provides an inter-frame time of 0.33 milliseconds and an A-scan spacing of 10 microns. A flow phantom, comprising a glass capillary tube of 80 μm inner diameter infused with unhomogenized milk by a syringe pump, was designed to test our OCT system mimicking the blood vessel. We collected 280 sequential B-scans at the same Y position of the phantom for a number of the velocity values. Based on variable interscan time analysis (VISTA) processing, we observed a strong correlation between the calculated decorrelation coefficients and the predetermined flow velocities, spanning a range from 0.16 mm/s to 30 mm/s. These findings enable us to explore our clinical hypotheses with in vivo tests.

Presenter

The Univ. of Sheffield (United Kingdom)
I received my MEng degree in Optical Engineering from Huazhong University of Science and Technology in 2019. During my postgraduate studies, I focused on quantitative research using laser-induced breakdown spectroscopy (LIBS) and developed a single-sample calibration method to improve the detection accuracy for major elements in samples like steel. In October 2020, I started my PhD programme at the University of Sheffield in the EEE Biophotonics group led by Professor Stephen Matcher. My current project aims to develop a high-speed near-IR OCT functional angiography system for quantifying blood flow velocity in cutaneous blood vessels, which is a promising imaging method for guiding the treatment of atopic dermatitis (AD).
Presenter/Author
The Univ. of Sheffield (United Kingdom)
Author
The Univ. of Sheffield (United Kingdom)
Author
The Univ. of Sheffield (United Kingdom)
Author
The Univ. of Sheffield (United Kingdom)