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11-16 April 2026
Conference 13006 > Paper 13006-44
Paper 13006-44

The potential application of visible light optical coherence tomography in skin barrier research

10 April 2024 • 14:00 - 14:20 CEST | Etoile B, Niveau/Level 1

Abstract

Stratum corneum (SC) biomarkers such as its thickness and hydration level offer valuable information about the state of the skin barrier. A Fourier domain visible light optical coherence tomography (VIS-OCT) system with an axial resolution of ~1 μm in tissue, was used to assess the morphology of the human SC layer under different hydration conditions. 12 human subjects (7 males, 5 females) in an age group of 21-59 were recruited. B-scan images of subjects’ dorsal hands were recorded by the VIS-OCT system and processed in MATLAB and GraphPad. An average SC thickness in the dorsal area before hydration, after hydration in water for 40 minutes and after drying in air for 40 minutes were found to be: 9 μm ± 0.1 μm, 19 μm ± 0.2 μm and 8 μm ± 0.1 μm, correspondingly. SC reflectance, obtained by VIS-OCT, changes at different hydration levels, increasing in a range of |4-12|dB during the hydration phase and decreasing in a range of |4-13|dB during the dehydration phase. That SC reflectance data correlates moderately to strongly, depending on an individual, with SC hydration levels measured by a Corneometer.

Presenter

The Univ. of Sheffield (United Kingdom)
I am doing my PhD under the supervision of Prof. Stephen Matcher at University of Sheffield on skin biomarker research. This PhD project largely involves the development & clinical application of novel skin imaging devices, especially optical coherence tomography, to establish and validate biomarkers of inflammatory skin disease such as AD, Psoriasis, systemic and localized Scleroderma, and graft-versus-host-disease.
Presenter/Author
The Univ. of Sheffield (United Kingdom)
Author
The Univ. of Sheffield (United Kingdom)
Author
The Univ. of Sheffield (United Kingdom)