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Conference 13006 > Paper 13006-6
Paper 13006-6

Raman spectroscopic phenotyping for the detection of infection-associated cell activation

9 April 2024 • 18:10 - 20:00 CEST | Galerie Schweitezer, Niveau/Level 0

Abstract

High-throughput screening Raman Spectroscopy (HTS-RS) is a breakthrough tool for clinical applications as it helps detect infection-associated cell activation. The technique captures the scattered light as a spectrum, presenting the sample's molecular signature. Machine learning methods are used to analyze the data confidently. Our study examined the influence of the interaction time between the virus and the cell on the spectral phenotype. HTS-RS has the potential to phenotype and identify cell activation associated with infections. This research could prove pivotal in developing effective strategies for diagnosing and treating the virus. Our findings provide a new information dimension of the cellular host response to virus infection.

Presenter

Hulya Yilmaz
Leibniz-Institut für Photonische Technologien e.V. (Germany), Abbe Ctr. of Photonics, Friedrich-Schiller-Univ. Jena (Germany)
Dr. Hulya Yilmaz is a scientist at Leibniz Institute of Photonic Technology (Leibniz-IPHT), Germany. She holds a Ph.D. in Analytical Chemistry and has prior experience as an EU Project Researcher at Sabancı University Nanotechnology Research and Application Center (SUNUM), Turkey. Dr. Yilmaz has also worked with renowned pharmaceutical companies like Pfizer Inc. and Kocak Pharma, gaining valuable industry experience.
Application tracks: AI/ML
Presenter/Author
Hulya Yilmaz
Leibniz-Institut für Photonische Technologien e.V. (Germany), Abbe Ctr. of Photonics, Friedrich-Schiller-Univ. Jena (Germany)
Author
Anuradha Ramoji
Leibniz-Institut für Photonische Technologien e.V. (Germany), Abbe Ctr. of Photonics, Friedrich-Schiller-Univ. Jena (Germany)
Author
Anja Silge
Leibniz-Institut für Photonische Technologien e.V. (Germany), Abbe Ctr. of Photonics, Friedrich-Schiller-Univ. Jena (Germany), Forschungcampus InfectoGnostics (Germany)
Author
Leibniz-Institut für Photonische Technologien e.V. (Germany)
Author
Karina Weber
Leibniz-Institut für Photonische Technologien e.V. (Germany), Forschungcampus InfectoGnostics (Germany)
Author
Leibniz-Institut für Photonische Technologien e.V. (Germany), Forschungcampus InfectoGnostics (Germany)
Author
Leibniz-Institut für Photonische Technologien e.V. (Germany)
Author
Leibniz-Institut für Photonische Technologien e.V. (Germany)
Author
Universitätsklinikum Jena (Germany)
Author
Universitätsklinikum Jena (Germany)
Author
Universitätsklinikum Jena (Germany)
Author
Leibniz-Institut für Photonische Technologien e.V. (Germany), Abbe Ctr. of Photonics, Friedrich-Schiller-Univ. Jena (Germany), Forschungcampus InfectoGnostics (Germany)