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11-16 April 2026
Conference 13006 > Paper 13006-87
Paper 13006-87

Photoacoustic, OCT, and Fluorescence Molecular Imaging Utilizing Gold Nanochains with Enhanced Renal Excretion

9 April 2024 • 18:10 - 20:00 CEST | Galerie Schweitezer, Niveau/Level 0

Abstract

Choroidal neovascularization (CNV) stands as the leading cause of vision loss in individuals afflicted with macular degeneration. Detecting CNV early and precisely determining its location accurately remains a formidable challenge with existing imaging methods. In this research, we introduce a multimodal triple imaging approach incorporating photoacoustic microscopy (PAM), optical coherence tomography (OCT), and fluorescence microscopy (FM) powered by gold nanoparticles to improve the precision of CNV diagnosis by harnessing the strengths of each modality. Nevertheless, conventional gold nanoparticle contrast agents have long-term safety concerns due to their accumulation in the liver and spleen. To overcome this issue, we have devised an innovative contrast agent founded on ultra-small gold nanospheres (GNS), which not only improves renal excretion but also enhances the contrast in PAM, OCT, and FM imaging. These ultra-small GNS were fabricated using pulsed laser ablation methods and subsequently surface-modified with CALNN peptides and cysteamine molecules, forming gold nanochains (GNC). Further surface conjugation with RGD peptides and indocyanine green (ICG) fluorescent dye

Presenter

Univ. of Michigan Kellogg Eye Ctr. (United States)
Presenter/Author
Univ. of Michigan Kellogg Eye Ctr. (United States)
Author
Univ. of Michigan (United States)
Author
Univ. of Michigan Kellogg Eye Ctr. (United States)