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Conference 13006 > Paper 13006-92
Paper 13006-92

Nonlinear multimodal imaging towards endoscopic applications

9 April 2024 • 18:10 - 20:00 CEST | Galerie Schweitezer, Niveau/Level 0

Abstract

Since its inception in the 1980s, CARS microscopy has greatly advanced, offering label-free imaging of molecular distributions and incorporating ultra-short pulse lasers to facilitate modalities like SHG and TPEF. Translating these nonlinear imaging methods for endoscopic clinical diagnostics involves challenges such as reducing background noise, miniaturizing probes, optimizing light transmission, and advancing data processing. Addressing these, we introduce two nonlinear endoscopic systems: a multicore fiber-based probe with proximal remote scanning and a custom reconstruction algorithm that enhances image readability, and a double-core double clad fiber based endoscope that allows background-free laser delivery and sub cellular resolution imaging. These systems promise potential to meet clinical requirements by providing detailed imaging performance comparable to conventional nonlinear microscopy.

Presenter

Hyeonsoo Bae
Leibniz-Institut für Photonische Technologien e.V. (Germany), Abbe Ctr. of Photonics, Friedrich-Schiller-Univ. Jena (Germany)
Based on studies of physics and photonics, my doctoral studies have been extended into a nonlinear imaging field at FSU Jena, Germany. The key part of my studies is translating nonlinear imaging techniques from microscope to endoscope for clinical applications, thereby providing characterization of essential components for such nonlinear endoscopic devices, and demonstrating them with various biological specimens.
Application tracks: EU-funded Research
Presenter/Author
Hyeonsoo Bae
Leibniz-Institut für Photonische Technologien e.V. (Germany), Abbe Ctr. of Photonics, Friedrich-Schiller-Univ. Jena (Germany)
Author
Matteo Calvarese
Abbe Ctr. of Photonics, Friedrich-Schiller-Univ. Jena (Germany), Leibniz-Institut für Photonische Technologien e.V. (Germany)
Author
Abbe Ctr. of Photonics, Friedrich-Schiller-Univ. Jena (Germany), Leibniz-Institut für Photonische Technologien e.V. (Germany)
Author
Anna Muehlig
Universitätsklinikum Jena (Germany)
Author
Grintech GmbH (Germany)
Author
Grintech GmbH (Germany)
Author
Grintech GmbH (Germany)
Author
Universitätsklinikum Jena (Germany)
Author
Abbe Ctr. of Photonics, Friedrich-Schiller-Univ. Jena (Germany)
Author
Abbe Ctr. of Photonics, Friedrich-Schiller-Univ. Jena (Germany), Leibniz-Institut für Photonische Technologien e.V. (Germany)