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Conference 13006 > Paper 13006-18
Paper 13006-18

Non-Invasive portable confocal Raman spectroscopy for comparative biochemical analysis of Atopic Dermatitis and Psoriasis skin

9 April 2024 • 09:20 - 09:40 CEST | Etoile B, Niveau/Level 1

Abstract

Atopic dermatitis (AD) and psoriasis are the two most prevalent skin disorders, often assessed through subjective questionnaires or visual evaluations conducted by clinicians, which can be subject to interpersonal variations. This study aims to explore the distinctions between these skin conditions and healthy skin using a portable confocal Raman spectroscopy (CRS) system for objective assessment. Spectral measurements at 671 nm and 785 nm on 9 AD, 6 psoriasis, and 11 healthy subjects reveal lower water content in AD compared to psoriasis and healthy skin. Ceramide subclasses show disease-specific trends, distinguishing AD, and psoriasis. Cholesterol levels further differentiate these conditions, with lower concentrations in lesional AD and significantly higher concentrations in lesional psoriasis compared to healthy skin. These differences contribute to the objective differentiation of skin conditions aiding in thorough assessment and treatment monitoring. Furthermore, it offers valuable insights for developing targeted disease-specific topical treatments.

Presenter

Keertana Vinod Ram
A*STAR Skin Research Labs., A*STAR Agency for Science, Technology and Research (Singapore)
Keertana Vinod Ram received her master’s by research (MEng) degree in biomedical engineering from the National University of Singapore, Singapore, in 2022. Her master’s thesis was focused on light sheet laser speckle imaging for blood flow monitoring in zebrafish embryos for non-invasive quantitative blood flow measurement capabilities. Currently, she holds the position of Research Officer at the Translational BioPhotonics Laboratory, Agency for Science, Technology, and Research (A*STAR) in Singapore and works on the application of Raman spectroscopy, diffuse reflectance spectroscopy, and photoacoustic imaging for the skin. Keertana's professional interests encompass BioPhotonics and biomedical spectral and image analysis, with a particular emphasis on developing medical applications that are translatable.
Presenter/Author
Keertana Vinod Ram
A*STAR Skin Research Labs., A*STAR Agency for Science, Technology and Research (Singapore)
Author
A*STAR Skin Research Labs., A*STAR Agency for Science, Technology and Research (Singapore)
Author
National Skin Ctr. Pte. Ltd. (Singapore)
Author
A*STAR Skin Research Labs., A*STAR Agency for Science, Technology and Research (Singapore)
Author
Biomedical Research Council, A*STAR Agency for Science, Technology and Research (Singapore)
Author
Valerie Teo Xinhui
A*STAR Skin Research Labs., A*STAR Agency for Science, Technology and Research (Singapore)
Author
A*STAR Skin Research Labs., A*STAR Agency for Science, Technology and Research (Singapore)
Author
National Skin Ctr. Pte. Ltd. (Singapore), A*STAR Agency for Science, Technology and Research (Singapore)
Author
National Skin Ctr. Pte. Ltd. (Singapore)
Author
A*STAR Skin Research Labs., A*STAR Agency for Science, Technology and Research (Singapore)