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Conference 13006 > Paper 13006-33
Paper 13006-33

Micro-scale assessment of breast cancer elasticity using optical coherence elastography (Invited Paper)

10 April 2024 • 08:30 - 09:00 CEST | Etoile B, Niveau/Level 1

Abstract

Optical coherence elastography (OCE) is an imaging technique capable of mapping mechanical properties (such as elasticity) in 3-D and is emerging as a valuable tool in the study and potential intraoperative diagnosis of breast cancer due to mechanical contrast between healthy and malignant tissue. While the correlation between elevated elasticity in OCE and breast cancers has been well established, these studies have primarily focused on binary classifications of tissue as either malignant or benign, ignoring much of the heterogeneity present in breast tissue. In this work, we present a detailed assessment of the microstructures present in human breast tissue images acquired with OCE, identifying regions of interest that corresponded to invasive carcinomas, in situ carcinomas and benign tissue types. We also describe the unique morphological patterns present in each tissue type and provide a framework for the interpretation of breast cancer images acquired with OCE.

Presenter

Rowan W. Sanderson
The Univ. of Western Australia (Australia), Harry Perkins Institute of Medical Research (Australia)
Dr Rowan Sanderson is a Research Associate in the School of Engineering at The University of Western Australia and a member of BRITElab at the Harry Perkins Institute of Medical Research. He received his PhD from The University of Western Australia in 2022. His doctoral thesis focussed on the development of novel probes for optical elastography. His current research focusses on the development of optical coherence tomography and optical elastography and their application in a range of fields, particularly oncology and surgery. He has published one book chapter and 15 peer-reviewed journal papers and holds one granted patent.
Presenter/Author
Rowan W. Sanderson
The Univ. of Western Australia (Australia), Harry Perkins Institute of Medical Research (Australia)
Author
The Univ. of Western Australia (Australia), Harry Perkins Institute of Medical Research (Australia)
Author
The Univ. of Western Australia (Australia), Harry Perkins Institute of Medical Research (Australia)
Author
The Univ. of Western Australia (Australia), Harry Perkins Institute of Medical Research (Australia)
Author
Fiona Stanley Hospital (Australia)
Author
Fiona Stanley Hospital (Australia)
Author
PathWest Lab. Medicine WA, Fiona Stanley Hospital (Australia), The Univ. of Western Australia (Australia), Clinipath Pathology (Australia)
Author
PathWest Lab. Medicine WA, Fiona Stanley Hospital (Australia)
Author
PathWest Lab. Medicine WA, Fiona Stanley Hospital (Australia)
Author
Fiona Stanley Hospital (Australia)
Author
Christobel M. Saunders
The Univ. of Melbourne (Australia), The Univ. of Western Australia (Australia)
Author
Brendan F. Kennedy
The Univ. of Western Australia (Australia), Harry Perkins Institute of Medical Research (Australia), Nicolaus Copernicus Univ. (Poland)