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11-16 April 2026
Conference 13006 > Paper 13006-88
Paper 13006-88

Linear and non-linear microspectroscopy: a powerful tool to study polymer-based nanoparticles in fibrotic liver cells.

9 April 2024 • 18:10 - 20:00 CEST | Galerie Schweitezer, Niveau/Level 0

Abstract

To investigate functionalized polymer-based nanoparticles (NPs) within cells and tissue, molecular selective microspectroscopic techniques are well suited. In our research we utilize confocal fluorescence microscopy and coherent anti-Stokes Raman scattering (CARS) microscopy to study the localization of NPs in cells and tissue. Raman spectroscopy in combination with two-dimensional correlation analysis (2DCOS) is utilized for the characterization of polymers, NPs, and drugs prior to its analysis in biological environments. Additionally, we utilize fluorescence lifetime microscopy (FLIM) to investigate the release of the encapsulated drug compounds of the functionalized NPs.

Presenter

Julian Plitzko
Friedrich-Schiller-Univ. Jena (Germany)
After studies of chemistry with a focus on physical and theoretical chemistry I am now in the second year of my doctoral research in the lab of Professor Popp at the FSU Jena, Germany. My research is affiliated with the CRC Polytarget, which focusses on the development of polymer-based drug delivery systems for the treatment of inflammation. The interest of my research is the characteri¬zation and spatiotemporal localization of such drug delivery systems in the size of nanoparticles in¬side of cells and tissue. A variety of linear and non-linear microspectroscopical tech¬niques are utilized to achieve deeper insights into the behavior of our nanoparticles.
Presenter/Author
Julian Plitzko
Friedrich-Schiller-Univ. Jena (Germany)