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11-16 April 2026
Conference 13006 > Paper 13006-19
Paper 13006-19

Label-free Cancer Cell Death Monitoring by Stimulated Raman Microscopy

9 April 2024 • 09:40 - 10:00 CEST | Etoile B, Niveau/Level 1

Abstract

We present a compact and portable stimulated Raman scattering (SRS) imaging system capable of high speed, label-free imaging of cells and tissues. Our setup rapidly acquires multispectral datasets with high chemical specificity by scanning the spectral range of 700-3100 1/cm in just 100 ms, providing a tenfold increase in acquisition speed. It allowed to visualize cell nucleus and cytoplasm changes during drug induced cancer cell death. SRS offers distinct advantages, providing valuable insights into drug-cell interactions, cell morphology, and chemical changes without the interference of exogenous labels. The novel high-speed SRS systems allows rapid screening of drug effects on cancer cells.

Presenter

Christoph Engwer
Refined Laser Systems GmbH (Germany)
Author
Refined Laser Systems GmbH (Germany)
Author
Refined Laser Systems GmbH (Germany)
Author
Refined Laser Systems GmbH (Germany)
Author
Biomedizinisches Technologiezentrum (Germany)
Author
Refined Laser Systems GmbH (Germany)
Author
Biomedizinisches Technologiezentrum (Germany)
Presenter/Author
Christoph Engwer
Refined Laser Systems GmbH (Germany)
Author
Biomedizinisches Technologiezentrum (Germany)
Author
Tim Hellwig
Refined Laser Systems GmbH (Germany)