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Conference 13006 > Paper 13006-13
Paper 13006-13

Label-free 3D NIR-SWIR “Spectromics” mapping of human hip cartilage for diagnosis of osteoarthritis

8 April 2024 • 17:00 - 17:20 CEST | Etoile B, Niveau/Level 1

Abstract

Osteoarthritis (OA), a degenerative joint disease presenting as loss of cartilage, is a leading cause of disability worldwide, increasingly with aging populations. Early detection is crucial for effective treatment since there is no definitive cure, yet, current assessment techniques fall short and rely on ionising radiation or invasive procedures. We report an application of multimodal “spectromics”, low-level abstraction data fusion of non-destructive NIR Raman and NIR-SWIR absorption spectroscopy, providing an enhanced, interpretable “fingerprint” for diagnosis of OA in human cartilage. Under multivariate statistical analyses and supervised machine learning, cartilage was classified with high precision and disease state predicted accurately. Discriminatory features within the spectromics fingerprint elucidated clinically relevant tissue components (OA biomarkers). Further, we have developed an automated goniometric 3D hyperspectral mapping setup, and characterised OA cartilage on whole human femoral heads post hip arthroplasty for spatially-resolved spectromics. These results lay foundation for minimally invasive, deeply penetrating, label-free, chemometric diagnosis of the hip.

Presenter

Hiroki Cook
Univ. of Southampton (United Kingdom)
Mr Hiroki Cook is a PhD student with the Molecular Biophotonics and Imaging group at the University of Southampton, UK. His research focuses on biomedical spectroscopic and laser-based techniques in the near- and shortwave infrared for label-free, non-destructive, deep-penetrating diagnostics and for photo-ablation treatments.
Application tracks: AI/ML
Presenter/Author
Hiroki Cook
Univ. of Southampton (United Kingdom)
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Univ. of Southampton (United Kingdom)
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Institut d'Optique Graduate School, Univ. de Bordeaux (France), Indian Institute of Technology Delhi (India)
Author
Univ. of Southampton (United Kingdom)
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Univ. of Southampton (United Kingdom)
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Univ. of Southampton (United Kingdom)
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Univ. of Southampton (United Kingdom)
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Sumeet Mahajan
Univ. of Southampton (United Kingdom)