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11-16 April 2026
Conference 13006 > Paper 13006-97
Paper 13006-97

Gray and white matter discrimination in ex-vivo cow brain tissue through polarimetric-based pseudocoloration methods

On demand | Presented live 9 April 2024

Abstract

Polarimetry comprises a set of noninvasive and nondesctructive optical techniques that demonstrated their great interest in biophotonics due to its capability to obtain relevant information from biological samples in a noninvasive and nondestructive way. Various polarimetric observables, derived from the Mueller matrix of a sample, are used to probe the efficacy of these techniques in pathology detection or different biological structures classification. The physical properties of a sample related to polarization can be categorized in three groups: retardance, dichroism and depolarization. In this work, we propose the study of the polarimetric observables linked to these physical properties for the identification of different structures within an ex-vivo cow brain sample by means of different pseudo-coloration methods. In particular, we study pseudo-coloration functions based on the Gaussian and Cauchy probabilistic functions. These probabilistic functions allow us to compute the probability of a given part of a sample to belong to a particular class (i.e. healthy or pathological or different structures inside the same sample) where, this probability depends on the polarimetric observables obtained from the studied sample. Our investigation encompasses a study of different observables and methodologies to find the optimal approach for brain tissue identification (identification of gray and white matter in ex-vivo cow brain) and, which may be of interest in multiple biomedical scenarios such as early pathology detection and diagnosis or enhanced visualization of different structures for clinical applications.

Presenter

Univ. Autònoma de Barcelona (Spain)
Mónica Canabal-Carbia is PhD student at the Optical Metrology and Image Processing Laboratory in the Universitat Autonoma de Barcelona. She received her BSc degree in physics at the University of Santiago de Compostels (USC) in 2020 and her MSc in Physics of the Light and Radiation at the USC in 2021. Her current thesis topic is framed in the field of polarization, studying the polarimetric response of biological tissue in light-matter interaction processes and developing polarimetric instrumentation and methods to be used in biomedical and botanical applications.
Presenter/Author
Univ. Autònoma de Barcelona (Spain)
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Univ. Autònoma de Barcelona (Spain)
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Univ. Autònoma de Barcelona (Spain)
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Univ. Autònoma de Barcelona (Spain)
Author
Univ. Autònoma de Barcelona (Spain)