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11-16 April 2026
Conference 13006 > Paper 13006-37
Paper 13006-37

Fractal-based contrast correction for defocus in full-field optical coherence tomography

10 April 2024 • 10:00 - 10:20 CEST | Etoile B, Niveau/Level 1


FFOCT (Full-field optical coherence tomography) is a high-resolution optical-sectioning imaging technique for biological tissues. Fractal analysis of the FFOCT image contrast is validated as a quantitative tool to measure the scattering properties of tissue. The defocus is one of the main factors that reduce FFOCT image contrast. This work applies the fractal analysis to model FFOCT image contrast. The contrast correction factor was proposed by considering tissue scattering and the system's defocused coherence transfer function. For each layer of the FFOCT image, the image is transformed to its original defocused amplitude and phase, then corrected with the proposed correction factor. The in-depth fractal dimension and EBCM (Edge-based contrast measurement) are introduced to validate the contrast enhancement quantitively. The result of the mouse organ demonstrated the correction effect quantitatively to a resolution limit, and it may guide a physics-informed interpretation of FFOCT and related augmented microscopy.


Nanjing Univ. of Science and Technology (China)
Dr. Zhu is Associate Professor of Department of Optical Engineering at Nanjing University of Science and Technology. She received her BS and Ph.D in Optical Engineering from Nanjing University of Science and Technology and completed her postdoctoral training in Electrical Engineering at Stanford University. Dr. Zhu is a member of the OSA and SPIE. Her research interests include biomedical optics and early diagnostics with machine learning. Currently she is visiting the Computational Optics Group at University of Tsukuba, working on OCT theory and device.
Nanjing Univ. of Science and Technology (China)
Zhenyan Guo
Nanjing Univ. of Science and Technology (China)
Xiaoyang Liu
Beijing Institute of Space Mechanics and Electricity (China)
Yuan Zhou
Zhejiang University School of Medicine (China)