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Conference 13006 > Paper 13006-71
Paper 13006-71

CANCELED: Exploring multiplexed near infrared fluorescence lifetime imaging in turbid media

9 April 2024 • 18:10 - 20:00 CEST | Galerie Schweitezer, Niveau/Level 0

Abstract

Fluorescence lifetime imaging (FLI) has a major influence on our comprehension of biological systems, serving as a potent instrument for non-invasive exploration of biomolecular and cellular dynamics, both in vitro and in vivo. Its capacity to selectively target and multiplex diverse entities, coupled with heightened sensitivity and specificity, furnishes rapid and cost-effective insights. In this study, we conduct an extensive examination of the multiplexing capabilities of near-infrared (NIR) FLI within a scattering medium that emulates biological tissues. We introduce an efficient, novel Monte Carlo (MC) simulation approach that describe the scattering behavior of fluorescent photons within turbid media. Subsequent application of phasor analyses enabled multiplexing of distinct targets within a single image. Leveraging the cutting-edge single-photon avalanche diode (SPAD) time-gated camera, SPAD512S, to perform experimental wide-field FLI in the NIR regime, we present the multiplexing of dual targets within a single image to a depth of 1 cm within tissue-like phantoms.

Presenter

Meital Harel
Ariel Univ. (Israel)
Name: Meital Harel E-mail: meitalh@ariel.ac.il Education 2023 PostDoc Physics, Ariel university. 2022 Ph.D. Physics, Bar Ilan University. 2008 M.Sc. Physics, Bar Ilan University – Graduated with honors. 2006 B.Sc. Physics, Bar Ilan University. Research 2023 Research in the Ankri lab on biomolecular Imaging and nanophotonics., Department of Physics, Ariel university. 2022 Graduate level research in the laboratory of Prof. Haim Taitelbaum on "Theoretical and experimental aspects of advancing interfaces", Department of Physics, Bar Ilan university. 2008 Masters level research in the laboratory of Prof. Haim Taitelbaum on "The effect of temperature on the dynamics and geometry of reactive-wetting interfaces", Department of Physics, Bar Ilan university – Graduated with honors.
Presenter/Author
Meital Harel
Ariel Univ. (Israel)