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Conference 13006 > Paper 13006-2
Paper 13006-2

Early detection of liver fibrosis through hepatic stellate cell activation monitoring using Raman spectroscopy and machine learning

8 April 2024 • 11:50 - 12:10 CEST | Etoile B, Niveau/Level 1

Abstract

The current methodology used to diagnose drug-induced liver injury (DILI) is rather exhaustive and complex. Using non-destructive Raman spectroscopy for high-content liver cell screening may offer an improved system for early DILI detection. This study explores the potential of Raman spectroscopy in tracking the progression of drug-induced liver fibrosis by monitoring the hepatic stellate cell (HSC) activation. We observed that the loss of retinoid content during HSC activation is accompanied by Raman spectral changes, allowing for discrimination between quiescent and activated HSCs based on their Raman data. This suggests that Raman spectroscopy can be ideal in drug-induced liver fibrosis detection during the drug development process.

Presenter

Margot Vandermotten
VUB B-PHOTONICS, Vrije Univ. Brussel (Belgium)
Margot Vandermotten is a PhD student at Brussels Photonics (B-PHOT) and the Liver Cell Biology research group (LIVR) from the Vrije Universiteit Brussel. She obtained her Bachelor’s degree in Electromechanical Engineering in 2019 and her Master’s degree in Biomedical Engineering in 2021 both from the Vrije Universiteit Brussel. She works under the supervision of Profs. Heidi Ottevaere, Wendy Meulebroeck and Leo van Grunsven and Dr. Tatevik Chalyan. Her research currently focuses on the use of optical detection techniques to identify the presence of Drug-Induced Liver Injuries (DILI) in liver in vitro models.
Application tracks: AI/ML
Presenter/Author
Margot Vandermotten
VUB B-PHOTONICS, Vrije Univ. Brussel (Belgium)
Author
Elisabeth Knetemann
Vrije Univ. Brussel, Liver Cell Biology Research Group (Belgium)
Author
VUB B-PHOTONICS, Vrije Univ. Brussel (Belgium)
Author
VUB B-PHOTONICS, Vrije Univ. Brussel (Belgium)
Author
Vrije Univ. Brussel (Belgium)
Author
VUB B-PHOTONICS, Vrije Univ. Brussel (Belgium)