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Conference 13006 > Paper 13006-23
Paper 13006-23

Computational Scattered Light Imaging for Label-Free Visualization of Fiber Architecture in Tumor Tissues

9 April 2024 • 11:40 - 12:00 CEST | Etoile B, Niveau/Level 1

Abstract

Studying fiber architectures in tumor tissues is of great importance as the cancer cells interact with fiber structures in the Extracellular Matrix (ECM). Computational Scattered Light Imaging (ComSLI) represents an innovative, non-destructive approach to whole-slide imaging with micrometer resolution, uniquely capable of accurately unraveling the complex, intertwined fiber structures in biological tissues. So far, it has been mainly used to study highly interwoven nerve fiber architectures in brain tissues. In this study, we extend the application of ComSLI to visualize fibers in diverse tumor tissues, including oral squamous cell carcinoma (OSCC) and colorectal cancer.

Presenter

Technische Univ. Delft (Netherlands), Erasmus MC (Netherlands)
Presenter/Author
Technische Univ. Delft (Netherlands), Erasmus MC (Netherlands)
Author
Loes Ettema
Technische Univ. Delft (Netherlands)
Author
Erasmus MC (Netherlands)
Author
Erasmus MC (Netherlands)
Author
Erasmus MC (Netherlands)
Author
Technische Univ. Delft (Netherlands)