See you in two years!
11-16 April 2026
Conference 13006 > Paper 13006-16
Paper 13006-16

Cardiorenal damage in heart failure with preserved ejection fraction: a spectroscopic study (Invited Paper)

9 April 2024 • 08:30 - 09:00 CEST | Etoile B, Niveau/Level 1

Abstract

Heart Failure with Preserved Ejection Fraction (HFpEF) is a severe medical condition. Concurrent pathologies linked with HFpEF create a complex scenario that contributes to structural and functional abnormalities in the heart and kidneys—the principal end organs affected by HFpEF. In this study, we assessed the effectiveness of a synergistic application of FTIR and Raman spectroscopy and multivariate/univariate statistical analyses to yield valuable pathophysiological insights in a rat model of heart failure. Peculiar biochemical differences were detected in the two organs demonstrating heightened sensitivity of these techniques towards the distinctive HFpEF phenotype.

Presenter

Paola Sassi
Univ. degli Studi di Perugia (Italy)
Paola Sassi is an associate professor of Physical Chemistry at the Department of Chemistry, Biology, and Biotechnology of the University of Perugia, Italy. She has an extensive publication record of more than 140 manuscripts and has trained numerous PhD students and postdoctoral fellows in the aspects of molecular spectroscopy. The main focus of her research is the chemico-physical study of biological processes and the characterization of cells and tissues using vibrational spectroscopy techniques.
Author
Leonardo Pioppi
Department of Chemistry, Biology and Biotechnology, University of Perugia (Italy)
Author
Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo (Norway)
Author
Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo (Norway)
Author
Department of Chemistry, Biology and Biotechnology, University of Perugia (Italy)
Author
Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo (Norway)
Presenter/Author
Paola Sassi
Univ. degli Studi di Perugia (Italy)