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11-16 April 2026
Conference 13006 > Paper 13006-102
Paper 13006-102

Raman glycoprobes for the detection of pathogenic fungi

On demand | Presented live 9 April 2024

Abstract

Antimicrobial Resistant (AMR) fungal pathogens do not respond to conventional treatments, causing lethal infections, especially in immunocompromised people. The urgent need for fast, reliable, and highly specific diagnostic methods to control this silent pandemic is evident. Raman Spectroscopy methods have great potential for the detection and identification of microbial pathogens, either label- free or using specific Raman tags and probes. We are developing carbohydrate-based Raman probes aiming to achieve selective pathogen detection inspired by the first steps of infection, during which pathogens adhere to the surface of host cells via carbohydrate-protein interactions. Previously, our group identified an aromatic-core divalent galactoside, that mimics host cell carbohydrates and recognizes Candida albicans, a critical priority fungal pathogen. We have synthesized thiol-bearing derivatives of this compound, which are attached to the surface of gold nanoparticles to create novel Raman glycoprobes capable of binding C. albicans. These novel glycoprobes will be studied for the capture, detection and chemical imaging of fungal pathogens, such as C. albicans.

Presenter

Timothy McNamara
National Univ. of Ireland, Maynooth (Ireland)
Timoth Mcnamara
Author
National Univ. of Ireland, Maynooth (Ireland)
Author
National Univ. of Ireland, Maynooth (Ireland)
Author
National Univ. of Ireland, Maynooth (Ireland)
Author
National Univ. of Ireland, Maynooth (Ireland)
Author
National Univ. of Ireland, Maynooth (Ireland)
Author
National Univ. of Ireland, Maynooth (Ireland)
Presenter/Author
Timothy McNamara
National Univ. of Ireland, Maynooth (Ireland)