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Conference 13006 > Paper 13006-17
Paper 13006-17

A multi-spectroscopic approach based on Brillouin and Raman microspectroscopy and ATR-FTIR spectroscopy to investigated Staphylococcus aureus – induced osteomyelitis and periprosthetic joint infections.

9 April 2024 • 09:00 - 09:20 CEST | Etoile B, Niveau/Level 1

Abstract

Staphylococcus aureus (SA) is the most commonly isolated aetiological agent of osteomyelitis and periprosthetic joint infection (PJI), a major public health problem in western countries. Infections usually result from bacterial spread through fractures or implants and their treatment requires removal of infected tissue, thorough cleansing of the wound and administration of antibiotics directly to the site of infection. Despite a precise surgical procedure, removal and replacement of the medical device is often necessary when an infected prosthesis is involved. Here we discuss a methodology for investigating the impact of SA infection on the structure and chemical composition of bone tissue, based on the integration of Raman-Brillouin microspectroscopy (BRamS) and AFT-FTIR spectroscopy. Our aim is to improve the understanding of the effects of SA infection on bone tissue and to identify specific markers that can be used for the detection of damaged tissue.

Presenter

Univ. degli Studi di Perugia (Italy)
Martina Alunni Cardinali is a researcher in the Molecular Spectroscopy Group at the Department of Chemistry, Biology, and Biotechnology, University of Perugia. Her work focuses on the application of vibrational spectroscopic techniques for biomedical applications.
Presenter/Author
Univ. degli Studi di Perugia (Italy)
Author
Marco Govoni
Reconstructive Orthopaedic Surgery and Innovative Techniques – Musculoskeletal Tissue Bank, IRCCS (Italy)
Author
Sara Stefani
Univ. degli Studi di Perugia (Italy)
Author
IRCCS, Istituto Ortopedico Rizzoli (Italy)
Author
IRCSS, Istituto Ortopedico Rizzoli (Italy)
Author
Reconstructive Orthopaedic Surgery and Innovative Techniques – Musculoskeletal Tissue Bank, IRCCS (Italy)
Author
Daniele Fioretto
Univ. degli Studi di Perugia (Italy)
Author
Paola Sassi
Univ. degli Studi di Perugia (Italy)