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Conference 13006 > Paper 13006-35
Paper 13006-35

A 1600nm optical coherence tomography platform for the assessment of skin inflammation caused by atopic dermatitis

10 April 2024 • 09:20 - 09:40 CEST | Etoile B, Niveau/Level 1

Abstract

Atopic dermatitis, or eczema, is a widespread chronic skin condition mainly treated with steroid creams, which can cause side effects such as skin thinning. Optical coherence tomography (OCT) allows for rapid non-invasive skin examination in the clinic. However, imaging depth at the popular 1300 nm wavelength is limited to ~1 mm due to scattering, making it difficult to assess severely inflamed skin. Skin optical properties, specifically scattering and absorption, vary with wavelength. Longer wavelengths centered at 1600 nm offer potential for deeper penetration due to lower scattering and minimal water absorption. Here we demonstrate a fiber-based, spectral-domain 1600 nm OCT system to study improvements in penetration depth in human skin. We use a supercontinuum laser source optimized for long-wavelength emission ranging from 1446 nm to 1694 nm to achieve high skin penetration depth, while maintaining an axial resolution of ~8-10 μm in the tissue (for the refractive index ranging n = 1.35 to 1.55 for different skin layers). Our system sensitivity is -90 dB at an A-scan rate of 76 kHz and approximately 8 mW of optical power on the skin. Simultaneous B-scans from a semi-transparent tape and human skin were obtained at 1600 nm and 1300 nm wavelengths, demonstrating and quantifying improvements in the imaging depth.

Presenter

The Univ. of Sheffield (United Kingdom)
Professor Stephen Matcher leads the biophotonics research group at the University of Sheffield, UK. He is a physicist, optical engineer, and bioengineer with over 25 years of experience in biophotonics. His primary research interest lies in the development and application of novel biophotonic imaging tools to aid in the characterization of native and engineered biological tissues. He extensively works with optical coherence tomography (OCT), including innovative variants such as polarization-sensitive OCT for non-invasive assessment of collagen organization and OCT angiography for measuring tissue vascularization. Currently, he collaborates with clinical colleagues to enhance the detection of bacterial and fungal eye infections, predict pre-term birth early with non-invasive tools, characterize skin barrier function, assess inflammatory skin disorders such as atopic dermatitis, and determine the biomechanical factors affecting the interaction between skin and man-made objects.
Author
Junaid Ahmad
The Univ. of Sheffield (United Kingdom)
Author
The Univ. of Sheffield (United Kingdom)
Author
The Univ. of Sheffield (United Kingdom)
Presenter/Author
The Univ. of Sheffield (United Kingdom)