Plenary Event
Hot Topics II
icon_in-person.svgIn person: 5 April 2022 • 16:30 - 18:05 CEST | Schweitzer Auditorium, Niveau/Level 0 
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Welcome and opening remarks

Francis Berghmans, Vrije Univ. Brussel (Belgium)
2022 Symposium Chair

Enhancing optical contrast for cancer detection and therapy guidance

Brian W. Pogue, Univ. of Wisconsin (United States) and Thayer School of Engineering, Dartmouth (United States)

Imaging systems naturally have a defined sensitivity and dynamic range, but the nature of imaging highly heterogenous diseases such as cancer means that the disease itself can partly define the image contrast and value of the image itself. In this talk, examples of endogenous structural imaging of tumor-associated collagen structures are used to illustrate the value of matching the spatial resolution to the features to be detected. In the area of exogenous contrast agents, this is also an area where the value of the added contrast may not be realized unless the imaging system is matched to the task, in terms of dynamic range and fidelity for resolving relevant cancer structures. The range of structural, metabolic, immunologic and genetic targeting features will be reviewed and examples of successful directions given for optical sensing during surgery and radiation therapy discussed. Commercial translation in these areas is now growing and scientific guidance can help to define the most promising areas for the future. Additionally new contrast mechanisms based upon fundamental physical interactions, such as Cherenkov-excited molecular sensing will be reviewed.

Brian Pogue recently accepted the role of Professor and Chair of the Department of Medical Physics at the University of Wisconsin-Madison in early 2022. He is also Adjunct Professor of Engineering at Dartmouth, in Hanover New Hampshire, where for 25 years he developed the Optics in Medicine research cluster and was co-director of both the translational engineering in cancer research and the Dartmouth medical physics PhD programs. During his tenure at Dartmouth, he was co-founder of Dartmouth's Centre for Imaging Medicine, as well as served as the Dean of Graduate Studies. After completing his PhD in Medical Physics from McMaster University in Canada, he completed a research fellowship at the Harvard Medical School and Massachusetts General Hospital before joining Dartmouth's faculty. Dr. Pogue's research is centered on developing innovative optical tools to advance radiation therapy and surgical guidance, photodynamic therapy, molecular imaging, and theranostics. In addition to publishing over 450 peer-reviewed journal articles, Dr. Pogue has received over $38 million in grant funding from the National Institutes of Health. Dr. Pogue is also president and co-founder of DoseOptics LLC, who are making the world's first camera system to image radiation dose in humans. Dr. Pogue is an elected fellow of the SPIE, Optica and AIMBE, and also serves as Editor-in-Chief of the Journal of Biomedical Optics.

Cell by lens: arguments and divagations for next visionary challenges in biophotonics and beyond

Pietro Ferraro, Institute of Applied Sciences and Intelligent Systems (ISASI-CNR) (Italy)

A new field is rapidly emerging in bio-photonics where living cells can act as real-world optical or photonic components. Live cells have well-defined optical characteristics that can be accurately characterized by interferometric instruments. Investigating and understanding the interactions between light and biological matter can unlock the full potential of this disruptive concept. It can be exploited in many circumstances as valuable tools in various fields of science and technology. Indeed, it is extraordinary as well as intriguing to discover that the optical behavior of living cells allows them to be used as imaging microlenses, photonic microresonators, or optical waveguides. Furthermore, it has been shown that biological cells can act as advanced optical tweezers or to enhance fluorescence microscopy. An overview of these fascinating biolenses applications will be illustrated and discussed.

Pietro Ferraro received the doctor of Physics degree, summa cum laude, from the University of Napoli "Federico II" in 1987. Soon after he joined Aeritalia-Alenia Aeronautics as researcher to develop applied research in optical non-destructive testing of carbon fiber materials. He has been principal investigator (1991-1993) on behalf of Composite Materials Research Center of Alenia for two R&D projects. In 1993 he joined Consiglio Nazionale delle Ricerche (CNR) Optics Group at Institute of Cybernetics, Pozzuoli, Italy as Associate Researcher to develop interferometric and holographic methods for testing and characterization of optical components and materials. In 2001 he joined as researcher at the CNR–Institute of Microelectronics and Microsystems in Napoli. In 2003 Pietro joined National Institute for Applied Optics (INOA) as Senior Research Scientist. Since 2005 he is head of the research line and group on behalf of CNR in optical diagnostics, Interferometric and Microscopy, and at present time he holds the position of the director of ISASI-CNR in Napoli. He is also the Vice-President elect of International Commission for Optics (ICO).

Dr. Ferraro has worked on a number of areas in optics research ranging from laser interferometry, holography for optical characterization of materials, components and devices, including MEMS-MOEMS, waveguides, optical fiber sensors, holographic lithography, micro- and nanostructuring of ferroelectric optical crystals (LiNbO3) for application in photonics. He has chaired many international conferences (SPIE, OPTICA, and IEEE). He is on the editorial board of Optics and Lasers in Engineering (Elsevier), topic editor of Biomedical Optics Express (OSA) and member of the editorial board of Light: Science & Applications (Springer- Nature) and Opto-Electronic Advances (OEA). He is Fellow of SPIE, Fellow of Optica, and Senior Member of IEEE. In 2020 he received the SPIE Gabor Award on Diffractive Optics.