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Kirill Larin

Dr. Kirill  Larin

Professor
University of Houston

Engineering
3605 Cullen Blvd
Room 2028
Houston TX 77204
United States

tel: 832-842-8834
E-mail: klarin@uh.edu
Web: http://www.egr.uh.edu/bol/

Area of Expertise

Biophotonics, Optical Coherence Tomography, laser-tissue interaction, bioimaging

Biography

Kirill V. Larin is an Associate Professor of Biomedical Engineering at the University of Houston. He also holds joint appointments at the Department of Physiology and Biophysics at Baylor College of Medicine and Department of Optics and Biophysics at the Saratov State University (Russia). Larin received his first M.S. in Laser Physics and Mathematics from the Saratov State University (1995), his second M.S. in Cellular Physiology and Molecular Biophysics (2001) and Ph.D. in Biomedical Engineering (2002) from the University of Texas Medical Branch in Galveston. Dr. Larin's research contributions are in Biomedical Optics and Biophotonics and development and application of various optical methods for noninvasive and nondestructive imaging and diagnostics of tissues and cells. The research projects in Dr. Larin's laboratory are supported in part by grants from NIH, NSF, DOD, and industrial collaborators. Larin has authored more than 60 peer-reviewed publications and chapters in six books on Biomedical Optics. He has received numerous awards including Presidential Award from Russian President Boris Yeltsin, Wallace Coulter Young Investigator Translation Award, Office of Naval Research Young Investigator Award, Outstanding Young Investigator Award from the Houston Society for Engineers in Medicine and Biology, and Herbert Allen Award from American Society for Mechanical Engineers. Dr. Larin has delivered more than 20 invited and plenary talks, serves as a co-chair of Dynamics and Fluctuations in Biomedical Photonics conference and a member of number technical committees at professional conferences. He is also an Instructor for short courses on Tissue Optics and Biophotonics for the SPIE, IEEE, and OSA.

Lecture Title(s)

Optical Coherence Tomography: imaging and sensing of tissues and cells: In this short course I will overview recent advances in development and application of Optical Coherence Tomography (OCT) technique for structural and functional imaging and sensing of various transport, developmental, and disease progression in tissues and cells. This course will start with basic description of light-tissue interaction including structural and optical models of tissues with single and multiple scattering. The theoretical and practical principles of Optical Coherence Tomography (OCT) will be discussed following by reviewing applications of OCT in many clinical and research fields (such as noninvasive monitoring of drug diffusion and optical clearing, sensing and quantifying of microbubbles and nanoparticles in tissues and blood, early diagnostics of arteriosclerosis, and imaging of early embryonic cardiovascular system development).

Tissue Optics and Optical Coherence Tomography: This course presents basic description of light-tissue interaction including structural and optical models of tissues with single and multiple scattering. Intensity- and spatially modulated, coherent and polarized light interactions with random and quasi-organized tissues will be considered. It will be shown that light reflection, transmission, scattering, and state of polarization can be effectively controlled by changes of tissue structure and the refractive index of tissue components. The concept of matching the refractive index of scatterers and ground matter by administration of chemical agents to control optical properties of tissues and blood will be discussed. Various medical optical diagnostic methods and instruments based on CW, time-resolved, and spatially resolved light scattering spectroscopy and tomography, speckle interferometry, confocal, and two-photon microscopy, and polarimetry will be presented. Special emphasis will be devoted to theory and applications of Optical Coherence Tomography (OCT) techniques. Applications of these methods and techniques to control tissue and blood optical properties; to monitor structure and image human tissues (such as skin, eye tissues, the body's interior tissues, the cerebral membrane, bone, cartilage, and tendon) will be discussed. Additionally, this course will overview recent developments in functional imaging of different tissues with OCT including noninvasive monitoring of drug diffusion and optical clearing, detection and assessment of microbubbles and nanoparticles in tissues and blood, early diagnostics of arteriosclerosis, and imaging of early embryonic cardiovascular system development. Outline: Part I: Introduction to Tissue Optics, Light scattering, coherence-domain, and polarimetric methods and techniques; Part II: Controlling of Tissue Optical Properties; Part III: Optical Coherence Tomography - principles; Part IV: Optical Coherence Tomography - applications

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