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Qiyin Fang

Dr. Qiyin  Fang, Ph.D.

Canada Research Chair in Biophotonics
McMaster University

ETB 403, School of Biomedical Engineering
McMaster University
1280 Main Street West
Hamilton ON L8S 4K1
Canada

tel: 905 525 9140 Ext. 24227
E-mail: qiyin.fang@mcmaster.ca

Biography

Qiyin Fang is currently an Associate Professor at McMaster University and holds the Canada Research Chair in Biophotonics.

Prior to joining McMaster, Dr. Fang was with the Minimally Invasive Surgical Technology Institute of Cedars-Sinai Medical Center in Los Angeles. Dr. Fang obtained his BSc (Physics) from Nankai University, his MSc (applied physics) and PhD (Biomedical Physics) from East Carolina University. His current research interests include optical spectroscopy and image guided minimally invasive diagnostic and therapeutic devices, miniaturized MOEMS sensors and imaging systems, and advanced optical microscopy and their emerging applications.

Lecture Title(s)

Time-resolved fluorescence spectroscopy and imaging: new tools for the old light 
Over the past two decade, fluorescence spectroscopy and imaging has emerged as an important tool in biomedicine, finding applications from visualization of cellular structures and intracellular processes to minimally invasive diagnosis. In addition to steady state spectra and intensity, the radiative decay time of the fluorescence process may be used as an additional source of contrast. Time-resolved fluorescence spectroscopy and imaging can simultaneously resolve multiple fluorophores with overlapping emission spectra but distinct lifetime thus can be used to distinguish different probes/markers. In addition, the sensitivity of lifetime to the microenviroment enables measurements of biochemically relevant indicators such us pH, ion concentration, oxygen consumption.
In this lecture, the fundamental challenges of detecting nanosecond to sub-nanosecond fluorescence decays and techniques to address these challenges (e.g. Time correlated single photon counting, intensified CCD, streak camera, etc.) will be discussed. Various new developments in time-domain fluorescence spectroscopy and imaging techniques will be introduced as well as their applications (e.g. minimally invasive medical diagnosis, high content cancer drug screening, etc.)

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