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Proceedings Paper

Towards a realistic numerical modeling of polarimetric response of healthy and pathological colon tissue
Author(s): Maria Rosaria Antonelli; Angelo Pierangelo; Tatiana Novikova; Pierre Validire; Abdelali Benali; Brice Gayet; Antonello De Martino
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Paper Abstract

We present Monte Carlo simulations of the backscattering of polarized light by colon tissue in terms of Mueller matrix. We validated the Monte Carlo code with measurements on aqueous suspensions of polystyrene spheres of different sizes. In a first instance we have modeled a tissue as a monodisperse scattering medium representing the nuclei in cytoplasm; then we included a second layer with monodisperse scatterers to represent the most superficial layers (mucosa and submucosa) while the deeper layers (muscularis and pericolic tissue) were "lumped" into a totally depolarizing lambertian. These simulations failed to reproduce the Rayleigh type scattering (larger depolarization for circular vs. linear incident polarization) systematically observed on all experimentally studied tissue samples. This issue has been solved by modelling tissues as a single layer of bimodal mixtures including large and small scatterers over a lambertian.

Paper Details

Date Published: 20 June 2011
PDF: 8 pages
Proc. SPIE 8087, Clinical and Biomedical Spectroscopy and Imaging II, 80872U (20 June 2011); doi: 10.1117/12.896635
Show Author Affiliations
Maria Rosaria Antonelli, LPICM, CNRS, Ecole Polytechnique (France)
Angelo Pierangelo, LPICM, CNRS, Ecole Polytechnique (France)
Tatiana Novikova, LPICM, CNRS, Ecole Polytechnique (France)
Pierre Validire, Institut Mutualiste Montsouris (France)
Abdelali Benali, Institut Mutualiste Montsouris (France)
Brice Gayet, Institut Mutualiste Montsouris (France)
Antonello De Martino, LPICM, CNRS, Ecole Polytechnique (France)

Published in SPIE Proceedings Vol. 8087:
Clinical and Biomedical Spectroscopy and Imaging II
Nirmala Ramanujam; Jürgen Popp, Editor(s)

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