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Proceedings Paper

Time-shifting correction in optoacoustic tomographic imaging for media with non-uniform speed of sound
Author(s): X. Luís Deán-Ben; Vasilis Ntziachristos; Daniel Razansky
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Paper Abstract

An analysis of the time-shifting correction in optoacoustic tomographic reconstructions for media with an a priori known speed of sound distribution is presented. We describe a modification of the filtered back-projection algorithm, for which the absorbed optical energy at a given point is estimated from the value of the measured signals at the instant corresponding to the time-of-flight between such point and the measuring points. In the case that a non-uniform speed of sound distribution does exist, we estimate the time-of-flight with the straight acoustic rays model, for which acoustic waves are assumed not to change direction as they propagate. The validity of this model is analysed for small speed of sound variations by comparing the predicted values of the time-of-flight with the ones estimated considering the refraction of the waves. Experimental results with tissue-mimicking agar phantoms with a higher speed of sound than water showcase the effects of the time-shifting of the optoacoustic signals caused by the acoustic mismatch. The performance of the time-shifting correction relates to the optoacoustic imaging of biological tissues, for which the speed of sound variations are usually lower than 10%.

Paper Details

Date Published: 16 June 2011
PDF: 9 pages
Proc. SPIE 8090, Novel Biophotonic Techniques and Applications, 809013 (16 June 2011); doi: 10.1117/12.889946
Show Author Affiliations
X. Luís Deán-Ben, Technical Univ. of Munich and Helmholtz Ctr. Munich (Germany)
Vasilis Ntziachristos, Technical Univ. of Munich and Helmholtz Ctr. Munich (Germany)
Daniel Razansky, Technical Univ. of Munich and Helmholtz Ctr. Munich (Germany)

Published in SPIE Proceedings Vol. 8090:
Novel Biophotonic Techniques and Applications
Henricus J. C. M. Sterenborg; I. Alex Vitkin, Editor(s)

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