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Proceedings Paper

Investigation of protein aggregation dynamics with a Bloch surface wave sensor
Author(s): Vincent Paeder; Sara Santi; Valeria Musi; Hans Peter Herzig
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Paper Abstract

We present a study of the dynamics of protein aggregation using a common path heterodyne Bloch surface wave sensing scheme. We demonstrate the ability to detect, during thermal incubation, the early events linked to the aggregation of proteins related to conformational diseases. Alzheimer's amyloid-β 1-42 is used to demonstrate the efficiency of the method. A model based on elementary interactions is shown to describe accurately the aggregation process. The described sensing scheme is sensitive to the early events of the aggregation process. is hence proposed as a method for the detection of early stages of the evolution of conformational diseases.

Paper Details

Date Published: 14 June 2011
PDF: 7 pages
Proc. SPIE 8090, Novel Biophotonic Techniques and Applications, 80900C (14 June 2011); doi: 10.1117/12.889698
Show Author Affiliations
Vincent Paeder, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Sara Santi, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Valeria Musi, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Hans Peter Herzig, Ecole Polytechnique Fédérale de Lausanne (Switzerland)

Published in SPIE Proceedings Vol. 8090:
Novel Biophotonic Techniques and Applications
Henricus J. C. M. Sterenborg; I. Alex Vitkin, Editor(s)

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