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Proceedings Paper

Surface-enhanced Raman spectroscopy differences of saliva between lung cancer patients and normal people
Author(s): Xiaozhou Li; Tianyue Yang; Siqi Li; Ting Yu
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Paper Abstract

Surface enhanced Raman spectroscopy (SERS) has shown the advantage of detecting low concentration biofluids presently. Saliva SERS of 21 lung cancer patients and 22 normal people were measured and differentiated in this paper. Intensities of most peaks of lung cancer patients are weaker than that of normal people, some are stronger but with a small change rate. Those peaks were assigned to proteins and nucleic acids which indicate a corresponding decrease of substance in saliva. Principal component analysis (PCA) and linear discriminant analysis (LDA) were used to deduce and discriminate the two groups of data, resulted in accuracy, sensitivity, and specificity being 84%, 94%, and 81%, respectively. In conclusion, SERS of saliva has the ability of predicting lung cancer.

Paper Details

Date Published: 14 June 2011
PDF: 5 pages
Proc. SPIE 8087, Clinical and Biomedical Spectroscopy and Imaging II, 808722 (14 June 2011); doi: 10.1117/12.889320
Show Author Affiliations
Xiaozhou Li, Shenyang Ligong Univ. (China)
Tianyue Yang, Shenyang Ligong Univ. (China)
Siqi Li, Solon High School (United States)
Ting Yu, Karlsruhe Univ. of Applied Sciences (Germany)

Published in SPIE Proceedings Vol. 8087:
Clinical and Biomedical Spectroscopy and Imaging II
Nirmala Ramanujam; Jürgen Popp, Editor(s)

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