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Proceedings Paper

The development of a combined b-mode, ARFI, and spectral Doppler ultrasound imaging system for investigating cardiovascular stiffness and hemodynamics
Author(s): Joshua R. Doherty; Douglas M. Dumont; Gregg E. Trahey
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Paper Abstract

The progression of atherosclerotic disease, caused by the formation of plaques within arteries, is a complex process believed to be a function of the localized mechanical properties and hemodynamic loading associated with the arterial wall. It is hypothesized that measurements of vascular stiffness and wall-shear rate (WSR) may provide important information regarding vascular remodeling, endothelial function, and the growth of soft-lipid filled plaques that could help a clinician better diagnose a patient's risk of clinical events such as stroke. To that end, the approach taken in this work was to combine conventional B-mode, Acoustic Radiation Force Impulse (ARFI), Shear Wave Elasticity Imaging (SWEI), and spectral Doppler techniques into a single imaging system capable of simultaneously measuring the tissue displacements and WSR throughout the cardiac cycle and over several heartbeats. Implemented on a conventional scanner, the carotid arteries of human subjects were scanned to demonstrate the initial in vivo feasibility of the method. Two non-invasive ultrasound based imaging methods, SAD-SWEI and SAD-Gated Imaging, were developed that measure ARF-induced on-axis tissue displacements, off-axis transverse wave velocities, and WSR throughout the cardiac cycle. Human carotid artery scans were performed in vivo on 5 healthy subjects. Statistical differences were observed in both on-axis proximal wall displacements and transverse wave velocities during diastole compared to systole.

Paper Details

Date Published: 25 March 2011
PDF: 10 pages
Proc. SPIE 7968, Medical Imaging 2011: Ultrasonic Imaging, Tomography, and Therapy, 796807 (25 March 2011); doi: 10.1117/12.877606
Show Author Affiliations
Joshua R. Doherty, Duke Univ. (United States)
Douglas M. Dumont, Duke Univ. (United States)
Gregg E. Trahey, Duke Univ. (United States)
Duke Univ. Medical Ctr. (United States)

Published in SPIE Proceedings Vol. 7968:
Medical Imaging 2011: Ultrasonic Imaging, Tomography, and Therapy
Jan D'hooge; Marvin M. Doyley, Editor(s)

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