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Proceedings Paper

2D/3D image fusion of x-ray mammograms with speed of sound images: evaluation and visualization
Author(s): Torsten Hopp; Julie Bonn; Nicole V. Ruiter; Mark Sak; Neb Duric
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Paper Abstract

Breast cancer is the most common cancer among women. The established screening method to detect breast cancer is X-ray mammography. However, X-ray frequently provides poor contrast of tumors located within glandular tissue. In this case, additional modalities like MRI are used for diagnosis in clinical routine. A new imaging approach is Ultrasound Computer Tomography, generating three-dimensional speed of sound images. High speed of sound values are expected to be an indicator of cancerous structures. Therefore, the combination of speed of sound images and X-ray mammograms may benefit early breast cancer diagnosis. In previous work, we proposed a method based on Finite Elements to automatically register speed of sound images with the according mammograms. The FEM simulation overcomes the challenge that X-ray mammograms show two-dimensional projections of a deformed breast whereas speed of sound images render a three-dimensional undeformed breast in prone position. In this work, 15 datasets from a clinical study were used for further evaluation of the registration quality. The quality of the registration was measured by the displacement of the center of a lesion marked in both modalities. We found a mean displacement of 7.1 mm. For visualization, an overlay technique was developed, which displays speed of sound information directly on the mammogram. Hence, the methodology provides a good basis for multimodal diagnosis using mammograms and speed of sound images. It proposes a guidance tool for radiologists who may benefit from the combined information.

Paper Details

Date Published: 25 March 2011
PDF: 8 pages
Proc. SPIE 7968, Medical Imaging 2011: Ultrasonic Imaging, Tomography, and Therapy, 79680L (25 March 2011); doi: 10.1117/12.877333
Show Author Affiliations
Torsten Hopp, Karlsruhe Institute of Technology (Germany)
Julie Bonn, Karlsruhe Institute of Technology (Germany)
Nicole V. Ruiter, Karlsruhe Institute of Technology (Germany)
Mark Sak, Karmanos Cancer Institute (United States)
Neb Duric, Karmanos Cancer Institute (United States)

Published in SPIE Proceedings Vol. 7968:
Medical Imaging 2011: Ultrasonic Imaging, Tomography, and Therapy
Jan D'hooge; Marvin M. Doyley, Editor(s)

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