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Proceedings Paper

Skeletonization approach for characterization of benign vs. malignant single thyroid nodules using 3D contrast enhanced ultrasound
Author(s): Filippo Molinari; Alice Mantovani; Maurilio Deandrea; Paolo Limone; Roberto Garberoglio; Jasjit S. Suri
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Paper Abstract

High-resolution ultrasonography (HRUS) has potentialities in differential diagnosis between malignant and benign thyroid lesions, but interpretative pitfalls remain and accuracy is still poor. We developed an image processing technique for characterizing the intra-nodular vascularization of thyroid lesions. Twenty nodules (ten malignant) were analyzed by 3-D contrast-enhanced ultrasound imaging. The 3-D volumes were preprocessed and skeletonized. Seven vascular parameters were computed on the skeletons: number of vascular trees (NT); vascular density (VD); number of branching nodes (or branching points) (NB); mean vessel radius (MR); 2-D (DM) and 3-D (SOAM) tortuosity; and inflection count metric (ICM). Results showed that the malignant nodules had higher values of NT (83.1 vs. 18.1), VD (00.4 vs. 0.01), NB (1453 vs. 552), DM (51 vs. 18), ICM (19.9 vs. 8.7), and SOAM (26 vs. 11). Quantification of nodular vascularization based on 3-D contrast-enhanced ultrasound and skeletonization could help differential diagnosis of thyroid lesions.

Paper Details

Date Published: 25 March 2011
PDF: 7 pages
Proc. SPIE 7968, Medical Imaging 2011: Ultrasonic Imaging, Tomography, and Therapy, 796813 (25 March 2011); doi: 10.1117/12.877128
Show Author Affiliations
Filippo Molinari, Politecnico di Torino (Italy)
Alice Mantovani, Politecnico di Torino (Italy)
Maurilio Deandrea, A. O. Ordine Mauriziano di Torino (Italy)
Paolo Limone, A. O. Ordine Mauriziano di Torino (Italy)
Roberto Garberoglio, Fondazione Scientifica Mauriziana ONLUS (Italy)
Jasjit S. Suri, Biomedical Technologies, Inc. (United States)
Idaho State Univ. (United States)

Published in SPIE Proceedings Vol. 7968:
Medical Imaging 2011: Ultrasonic Imaging, Tomography, and Therapy
Jan D'hooge; Marvin M. Doyley, Editor(s)

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