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Proceedings Paper

Photodynamic therapy on bladder cancer cells: further studies on the performance of Coimbra sensitizers
Author(s): Antonio M. d'A. Rocha Gonsalves; Arménio C. Serra; Marta Pineiro; M. Filomena Botelho
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Paper Abstract

Following previous studies where we developed some high performance porphyrin derivatives for photodynamic therapy demonstrating their activity in different cell lines, we now extend our attention to CRL1472 bladder cancer line. In this work the phototoxicity of several diaryl and tetraarylporphyrins with different structures were evaluated with different incubation times. The phototoxicity observed was not directly related to the concentration of photosensitizer inside cells. Uptake studies demonstrate that the brominated derivative 2 which despite the most efficient photosensitizer presents a poor tendency to enter into cells.

Paper Details

Date Published: 17 May 2010
PDF: 8 pages
Proc. SPIE 7715, Biophotonics: Photonic Solutions for Better Health Care II, 77151N (17 May 2010); doi: 10.1117/12.854608
Show Author Affiliations
Antonio M. d'A. Rocha Gonsalves, Univ. de Coimbra (Portugal)
Arménio C. Serra, Univ. de Coimbra (Portugal)
Marta Pineiro, Univ. de Coimbra (Portugal)
M. Filomena Botelho, Univ. de Coimbra (Portugal)

Published in SPIE Proceedings Vol. 7715:
Biophotonics: Photonic Solutions for Better Health Care II
Jürgen Popp; Wolfgang Drexler; Valery V. Tuchin; Dennis L. Matthews, Editor(s)

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