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Proceedings Paper

ZnO and TiO2 particles: a study on nanosafety and photoprotection
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Paper Abstract

Nanoparticles of titanium dioxide (TiO2) and zinc oxide (ZnO) are used in sunscreens as protective compounds against UV radiation. We investigate these particles from the viewpoint of nanosafety (penetration into skin in vivo, production of free radicals when UV-irradiated) as well as UV protection. We show that: a) even after multiple applications, the particles remain within stratum corneum (uppermost skin layer); b) the optimal sizes are 62 nm and 45 nm, respectively for TiO2 and ZnO particles for 310-nm light and, correspondingly, 122 and 140 nm - for 400-nm radiation; c) in general, small particles (25 nm in diameter) are more photoactive than the larger ones (400 nm in diameter); however, on the background if porcine skin in vitro this difference is not seen and is substantially surpassed by skin contribution into production of free radicals.

Paper Details

Date Published: 18 May 2010
PDF: 7 pages
Proc. SPIE 7715, Biophotonics: Photonic Solutions for Better Health Care II, 77153G (18 May 2010); doi: 10.1117/12.854561
Show Author Affiliations
Alexey Popov, Univ. of Oulu (Finland)
Lomonosov Moscow State Univ (Russian Federation)
Xin Zhao, Macquarie Univ. (Australia)
Andrei Zvyagin, Macquarie Univ. (Australia)
Jürgen Lademann, Charité Universitätsmedizin Berlin (Germany)
Michael Roberts, The Univ. of Queensland (Australia)
Washington Sanchez, The Univ. of Queensland (Australia)
Alexander Priezzhev, Lomonosov Moscow State Univ. (Russian Federation)
Risto Myllylä, Univ. of Oulu (Finland)

Published in SPIE Proceedings Vol. 7715:
Biophotonics: Photonic Solutions for Better Health Care II
Jürgen Popp; Wolfgang Drexler; Valery V. Tuchin; Dennis L. Matthews, Editor(s)

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