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Proceedings Paper

Integrated micro-total analysis system (uTAS) for biophotonic enzymatic detections
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Paper Abstract

Lab-on-a-chip or Micro total analysis systems (μTAS) technologies offer a lot of potential applications for biosensing and biomedical detections. This paper presents the design, fabrication and characterization of a fully integrated siliconpolymer based biophotonic Micro-Total Analysis System for the real-time detection of enzymes and antigens. This device uses optical detection methods i.e, optical absorption, Laser induced fluorescence and evanescence measurement technique to detect the presence, concentration and the activity of biomolecules. The main components of the proposed system are microfluidic unit and micromechanical fluid actuation system, integrated with the optical detection systems. An Echelle grating based Spectrometer-on-Chip on Silica-on-Silicon (SOS) is integrated with the opto-microfluidic assembly for fluorescence detection. On-Chip fabrication and integration of valveless micropump has been carried out in order to facilitate the transportation of fluid within the system. The important advantages of the proposed μTAS are functional independence of each module of the system, simultaneous multi-analyte detection, rapid, precise and discriminating results, low background/high signal-to-noise ratio, lack of moving parts, robust, portability, and feasibility of bulk fabrication.

Paper Details

Date Published: 22 February 2010
PDF: 7 pages
Proc. SPIE 7555, Advanced Biomedical and Clinical Diagnostic Systems VIII, 75551D (22 February 2010); doi: 10.1117/12.843718
Show Author Affiliations
Arvind Chandrasekaran, Concordia Univ. (Canada)
Muthukumaran Packirisamy, Concordia Univ. (Canada)

Published in SPIE Proceedings Vol. 7555:
Advanced Biomedical and Clinical Diagnostic Systems VIII
Tuan Vo-Dinh; Warren S. Grundfest M.D.; Anita Mahadevan-Jansen, Editor(s)

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