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Proceedings Paper

Enhanced PNA detection sensitivity based on polymer-cladded porous silicon waveguide
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Paper Abstract

In this work, we theoretically and experimentally demonstrate a highly sensitive polymer-cladded porous silicon (PSi) membrane waveguide based on a ~1.55 μm thick porous silicon membrane coated on one side with a low loss polymer. The sensor operates in the Kretschmann configuration, which is amenable to microfluidics integration, with a high index cubic zirconium prism. The sensitivity of the sensor is investigated through PNA hybridization in the PSi membrane. We demonstrate that higher angle resonances and a proper ratio of PNA length to PSi pore diameter lead to significantly improved detection sensitivity. A detection sensitivity below 0.1°/μM is reported for 16mer target PNA. Calculations and complimentary experiments show that careful tuning of the polymer cladding thickness can further improve the detection performance.

Paper Details

Date Published: 25 February 2010
PDF: 7 pages
Proc. SPIE 7553, Frontiers in Pathogen Detection: From Nanosensors to Systems, 75530O (25 February 2010); doi: 10.1117/12.842258
Show Author Affiliations
Yang Jiao, Vanderbilt Univ. (United States)
Sharon M. Weiss, Vanderbilt Univ. (United States)

Published in SPIE Proceedings Vol. 7553:
Frontiers in Pathogen Detection: From Nanosensors to Systems
Philippe M. Fauchet; Benjamin L. Miller, Editor(s)

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