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Proceedings Paper

Selective cancer therapy via IR-laser-excited gold nanorods
Author(s): Jui-Teng Lin; Yu-Ling Hong; Chun-Lin Chang
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Paper Abstract

This study evaluated the effectiveness of near-infrared laser-excited gold nanorods as the active target to selectively kill the cancer cells. The key parameters of laser and sample to be measured include the absorption coefficient, the laser fluence and irradiation time, and the temperature profiles. The optimal laser operation for the surface and volume heating was achieved by a novel pulsed-train technique using an auto-controlled laser on-off time to meet the desired temperatures. The measured temperature is an increasing function of laser fluence and irradiation time. For a fixed laser influence, GNRs solution with smaller extinction coefficients (A) provides higher volume temperature, but slower surface raising speed. This novel measured features are predicted by our theory based on a heat diffusion equation, which was solved numerically, for volume heating.

Paper Details

Date Published: 25 February 2010
PDF: 5 pages
Proc. SPIE 7562, Optical Interactions with Tissues and Cells XXI, 75620R (25 February 2010); doi: 10.1117/12.841348
Show Author Affiliations
Jui-Teng Lin, National Taiwan Univ. (Taiwan)
Yu-Ling Hong, National Taiwan Univ. (Taiwan)
Chun-Lin Chang, National Taiwan Univ. (Taiwan)

Published in SPIE Proceedings Vol. 7562:
Optical Interactions with Tissues and Cells XXI
E. Duco Jansen; Robert J. Thomas, Editor(s)

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