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Proceedings Paper

Image analysis software for following progression of peripheral neuropathy
Author(s): Thomas Epplin-Zapf; Clayton Miller; Sean Larkin; Eduardo Hermesmeyer; Jenny Macy; Marco Pellegrini; Saverio Luccarelli; Giovanni Staurenghi; Timothy Holmes
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Paper Abstract

A relationship has been reported by several research groups [1 - 4] between the density and shapes of nerve fibers in the cornea and the existence and severity of peripheral neuropathy. Peripheral neuropathy is a complication of several prevalent diseases or conditions, which include diabetes, HIV, prolonged alcohol overconsumption and aging. A common clinical technique for confirming the condition is intramuscular electromyography (EMG), which is invasive, so a noninvasive technique like the one proposed here carries important potential advantages for the physician and patient. A software program that automatically detects the nerve fibers, counts them and measures their shapes is being developed and tested. Tests were carried out with a database of subjects with levels of severity of diabetic neuropathy as determined by EMG testing. Results from this testing, that include a linear regression analysis are shown.

Paper Details

Date Published: 24 February 2009
PDF: 6 pages
Proc. SPIE 7169, Advanced Biomedical and Clinical Diagnostic Systems VII, 71691C (24 February 2009); doi: 10.1117/12.814672
Show Author Affiliations
Thomas Epplin-Zapf, Lickenbrock Technologies, LLC (United States)
Washington Univ. (United States)
Clayton Miller, Lickenbrock Technologies, LLC (United States)
Sean Larkin, Lickenbrock Technologies, LLC (United States)
Eduardo Hermesmeyer, Lickenbrock Technologies, LLC (United States)
Jenny Macy, Lickenbrock Technologies, LLC (United States)
Marco Pellegrini, Univ. degli Studi di Milano (Italy)
Saverio Luccarelli, Univ. degli Studi di Milano (Italy)
Giovanni Staurenghi, Univ. degli Studi di Milano (Italy)
Timothy Holmes, Lickenbrock Technologies, LLC (United States)

Published in SPIE Proceedings Vol. 7169:
Advanced Biomedical and Clinical Diagnostic Systems VII
Anita Mahadevan-Jansen; Tuan Vo-Dinh; Warren S. Grundfest M.D., Editor(s)

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