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Proceedings Paper

Development of a high-speed CT imaging system using EMCCD camera
Author(s): Samta C. Thacker; Kai Yang; Nathan Packard; Valeriy Gaysinskiy; George Burkett; Stuart Miller; John M. Boone; Vivek Nagarkar
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Paper Abstract

The limitations of current CCD-based microCT X-ray imaging systems arise from two important factors. First, readout speeds are curtailed in order to minimize system read noise, which increases significantly with increasing readout rates. Second, the afterglow associated with commercial scintillator films can introduce image lag, leading to substantial artifacts in reconstructed images, especially when the detector is operated at several hundred frames/second (fps). For high speed imaging systems, high-speed readout electronics and fast scintillator films are required. This paper presents an approach to developing a high-speed CT detector based on a novel, back-thinned electron-multiplying CCD (EMCCD) coupled to various bright, high resolution, low afterglow films. The EMCCD camera, when operated in its binned mode, is capable of acquiring data at up to 300 fps with reduced imaging area. CsI:Tl,Eu and ZnSe:Te films, recently fabricated at RMD, apart from being bright, showed very good afterglow properties, favorable for high-speed imaging. Since ZnSe:Te films were brighter than CsI:Tl,Eu films, for preliminary experiments a ZnSe:Te film was coupled to an EMCCD camera at UC Davis Medical Center. A high-throughput tungsten anode X-ray generator was used, as the X-ray fluence from a mini- or micro-focus source would be insufficient to achieve high-speed imaging. A euthanized mouse held in a glass tube was rotated 360 degrees in less than 3 seconds, while radiographic images were recorded at various readout rates (up to 300 fps); images were reconstructed using a conventional Feldkamp cone-beam reconstruction algorithm. We have found that this system allows volumetric CT imaging of small animals in approximately two seconds at ~110 to 190 μm resolution, compared to several minutes at 160 μm resolution needed for the best current systems.

Paper Details

Date Published: 13 March 2009
PDF: 7 pages
Proc. SPIE 7258, Medical Imaging 2009: Physics of Medical Imaging, 725846 (13 March 2009); doi: 10.1117/12.813712
Show Author Affiliations
Samta C. Thacker, Radiation Monitoring Devices, Inc. (United States)
Kai Yang, Univ. of California, Davis Medical Ctr. (United States)
Nathan Packard, Univ. of California, Davis Medical Ctr. (United States)
Valeriy Gaysinskiy, Radiation Monitoring Devices, Inc. (United States)
George Burkett, Univ. of California, Davis Medical Ctr. (United States)
Stuart Miller, Radiation Monitoring Devices, Inc. (United States)
John M. Boone, Univ. of California, Davis Medical Ctr. (United States)
Vivek Nagarkar, Radiation Monitoring Devices, Inc. (United States)

Published in SPIE Proceedings Vol. 7258:
Medical Imaging 2009: Physics of Medical Imaging
Ehsan Samei; Jiang Hsieh, Editor(s)

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