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Proceedings Paper

Association between lung function and airway wall density
Author(s): J. Ken Leader; Bin Zheng; Carl R. Fuhrman; John Tedrow; Sang C. Park; Jun Tan; Jiantao Pu; John M. Drescher; David Gur; Frank C. Sciurba
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Paper Abstract

Computed tomography (CT) examination is often used to quantify the relation between lung function and airway remodeling in chronic obstructive pulmonary disease (COPD). In this preliminary study, we examined the association between lung function and airway wall computed attenuation ("density") in 200 COPD screening subjects. Percent predicted FVC (FVC%), percent predicted FEV1 (FEV1%), and the ratio of FEV1 to FVC as a percentage (FEV1/FVC%) were measured post-bronchodilator. The apical bronchus of the right upper lobe was manually selected from CT examinations for evaluation. Total airway area, lumen area, wall area, lumen perimeter and wall area as fraction of the total airway area were computed. Mean HU (meanHU) and maximum HU (maxHU) values were computed across pixels assigned membership in the wall and with a HU value greater than -550. The Pearson correlation coefficients (PCC) between FVC%, FEV1%, and FEV1/FVC% and meanHU were -0.221 (p = 0.002), -0.175 (p = 0.014), and -0.110 (p = 0.123), respectively. The PCCs for maxHU were only significant for FVC%. The correlations between lung function and the airway morphometry parameters were slightly stronger compared to airway wall density. MeanHU was significantly correlated with wall area (PCC = 0.720), airway area (0.498) and wall area percent (0.611). This preliminary work demonstrates that airway wall density is associated with lung function. Although the correlations in our study were weaker than a recent study, airway wall density initially appears to be an important parameter in quantitative CT analysis of COPD.

Paper Details

Date Published: 27 February 2009
PDF: 9 pages
Proc. SPIE 7262, Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging, 72622J (27 February 2009); doi: 10.1117/12.811768
Show Author Affiliations
J. Ken Leader, Univ. of Pittsburgh (United States)
Bin Zheng, Univ. of Pittsburgh (United States)
Carl R. Fuhrman, Univ. of Pittsburgh (United States)
John Tedrow, Univ. of Pittsburgh (United States)
Sang C. Park, Univ. of Pittsburgh (United States)
Jun Tan, Univ. of Pittsburgh (United States)
Jiantao Pu, Univ. of Pittsburgh (United States)
John M. Drescher, Univ. of Pittsburgh (United States)
David Gur, Univ. of Pittsburgh (United States)
Frank C. Sciurba, Univ. of Pittsburgh (United States)

Published in SPIE Proceedings Vol. 7262:
Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging
Xiaoping P. Hu; Anne V. Clough, Editor(s)

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